2-Deoxy-D-glucose Poda

Zita rechigadzirwa: 2-Deoxy-D-glucose;2-DG
CAS: 154-17-6
MF:C6H12O5
MW:164.16
Package: 500g / bhegi; 1kg / bhegi
Origin: China
Kugovera Mano: 100kg pamwedzi
Muenzaniso Uripo: Hongu
Kubhadhara: T/T, LC kana DA
Certifications: ISO9001, ISO22000, HACCP, HALAL, KOSHER
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Product Introduction

2-Deoxy-D-glucose hupfu Mutengesi

Xi'an Yihui Kambani inyanzvi mugadziri wezvakanakisa 2-Deoxy-D-glucose hupfu. Tinogona kugadzira 2DG ine 99.9% yemukati. Inogona kushandiswa mukudya, mushonga, zvinhu zvehutano, kana zvizorwa uye inosangana neUSP, BP, EP, CP zviyero. Tinogona kukupa zvigadzirwa zvemhando yepamusoro pamitengo inokwikwidza. Yako yakanakisa sarudzo kune ane mukurumbira yakachena 2DG mutengesi ndeye Xi'an Yihui Kambani!


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Chii chinonzi 2-Deoxy-D-glucose powder?

2- Deoxy- D-glucose poda ikemikari, chimiro chayo chemakemikari ndeyeC6H12O5 uye uremu hwayo hwema molecular ndeye 164.16 g / spook, yayo CAS NO. ndizvo 154-17-6. Ishuga yekabhoni matanhatu yakafanana neglucose, asi isina boka rehydroxyl pane imwe kabhoni snippet, nekudaro inonzi "deoxy" glucose. Iyo chena demitasse ine yakaderera solubility mumvura. 2DG ikiriniki yemetabolism disruptor iyo inogona kuvharira sero glucose kutora uye kushandisa, zvichiita kuti kudonha kweATP mamiriro mukati memasero.

Mushonga uyu unonyanya kushanda pamasero ebundu uye mamwe hutachiona hunovimba neshuga seyavo huru metabolic substrate. Kushandisa 2DG kunogona kuita kuti maseru aya afe kana kudzikisira kukura kwawo. Pamusoro pezvo, 2DG inoshandiswa sechishandiso mukutsvaga neuroscience uye metabolism nekuti inogona kutevedzera mamiriro ekuneta kwemetabolism, ichiburitsa ruzivo rwemaserura metabolic nzira.

Kuwanikwa kwe2-Deoxy-D-glucose kunogona kurondwa kumashure kwekutanga 1950s. Panguva iyoyo, masayendisiti ekuAmerica Haskell Smith naMorris Ficher vakawana emulsion inonzi 2-deoxyglucose vachidzidza nzira dzekutora glucose. Gare gare, mumwe musayendisiti Takashi Otsuka akawana kuti 2-deoxy glucose inogona kupindira nesero glucose metabolism uye inhibisa kupatsanurwa kwesero panguva yekusangana kweDNA.

Gare gare, masayendisiti akaita kumwe kuongorora 2-DG hupfu uye kumisikidza kuti inogona kutadzisa kukura kwemamwe maseru uye hutachiona asi paine zvinhu zvishoma pamaseru akajairwa.

Kuti kuwedzere kushanda kwe2DG, masayendisiti akatanga kugadzira nekugadzira anologous motes. Mukuita uku, ivo vakamisa kuti 2DG yaive yakanyanya kushanda metabolic disruptor, inokwanisa kunyatso kuvharisa cell glucose kutora uye kushandisa. Parizvino, 2DG yave chishandiso chakakosha chekuyedza uye mushonga wekiriniki.

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Basic Information

Product zita

2-Deoxy-D-glucose

Rimwe zita

kusanganiswa kweanomers; 2-Deoxy-D-Arabino; 2-deoxy-D-glucose giredhi iii; 2-deoxy-D-glucose giredhi ii; Deoxy-d-glucose; 2-deoxyhexopyranose;2-deoxy-D-arabino-hexose; 2-deoxy-alpha-D-arabino-hexopyranose;2-deoxy-D-arabino-hexopyranose; 2-deoxy-D-glucose sigmaultra; 2-deoxy-beta-D-arabino-hexopyranose

CAS

154-17-6

MF

C6H12O5

MW

164.16

EINECS

205-823-0

MDL Nha.

MFCD00151328

Purity

99%

Kuramba

yakagadzikana kana yakachengetwa pasi pemamiriro akakodzera.

solubility

Zvishoma soluble mumvura

kunyoresa

Mushonga giredhi kana kushandiswa kutsvaga.

chiputiriso

Sekukumbira kwako

chengetedzo

Tembiricha yekamuri.

Structural formula

154-17-6.webp


Quality standard

chinhu

Specification

Analysis Result

Kuonekwa

Muchena kana hupfu huchena

White powder

Chiratidzo

Positive

Positive

Specific optical rotation

+45.0°--+47.5°

+ 46.3 °

Zviremera zvakasimba

10ppm Max

<10ppm

Kupererwa neKuoma

1.0% Max

0.30%

Assay

98.0%

98.86%

Gara patsva

0.2% Max

0.07%

Synthesis Process

Iyo synthesis process ye 2-deoxy-D-glucose pouder inosanganisira matanho maviri:

Muchikamu chekutanga, glucose inoiswa pasi peKnoevenagel condensation nekuita nemethyl vinyl ketone kuti ibudise α, β-unsaturated carbonyl compound.

Muchikamu chechipiri, tIyo unsaturated compound yakaderedzwa kusvika kune chinangwa chigadzirwa 2-deoxy-D-glucose kuburikidza nekuderedza hydrogenation.

Heano maitiro chaiwo ekuita:

Danho rekutanga reaction equation:

Glucose + Methyl vinyl ketone → α,β-unsaturated carbonyl compound

Yekutanga nhanho reaction mechanism:

Pasi pemamiriro e-alkaline, glucose uye methyl vinyl ketone inoshanda se nucleophilic reagents uye inopinda Knoevenagel condensation nerubatsiro rwe thioacetone kana sodium hydroxide, ichipa α, β-unsaturated carbonyl compound.

Chechipiri nhanho reaction equation:

α,β-unsaturated carbonyl compound + Hydrogen gas + Catalyst → 2-deoxy-D-glucose

Chechipiri danho rekuita maitiro:

Muhupo hwehaidhirojeni gasi uye chinokonzera, iyo-unsaturated carbonyl emulsion inonzi hydrogenated kuti ibudise 2-deoxy-D-glucose. A essence catalyst yakafanana neplatinamu kana precaution inowanzo shandiswa kune iyi hydrogenation mhinduro.

Izvo zvinofanirwa kucherechedzwa kuti ingori imwe yakajairika maitiro ekugadzira 2-deoxy-D-glucose. Muchokwadi, kune dzimwe nzira dzakasiyana dzekugadzira, dzakafanana nekemikari revision yeuracil uye microbial metabolism.

musanganiswa wakakosha unoshandiswa zvakanyanya mukurapa, biotechnology, uye indasitiri yezvekudya. Heano mamwe mabhenefiti ayo:

Iyo haina chepfu mhedzisiro pamuviri wemunhu uye ine yakasarudzika kuuraya maitiro pamasero egomarara;

Iine anti-virus, antifungal, anti-diabetes, anti-obesity uye mamwe maitiro;

Inogona kutorwa uye kushandiswa nemuviri wemunhu;

Inogona kushandiswa seredhiyo yakanyorwa neredhiyo kana DNA kugadzirisa agent mu biotechnology;

Inogona kushandiswa seyakaderera-calorie sweetener muindasitiri yezvokudya;

Muchidimbu, iri musanganiswa unobatsira une akasiyana maapplication.

Chii Chiri Basa re2 Deoxy Glucose?

2 deoxy glucose(2DG) is a glucose analogue inoshaya hydroxyl group pa 2- position ye glucose ring. Inowanzo shandiswa mukutsvagisa kwesainzi sechombo chekuongorora glucose metabolism uye nzira dzayo dzakabatana. Heano mamwe mabasa ayo:

1. Asset ye glycolysis 2DG inotorwa nemasero kuburikidza nevatakuri veglucose uye phosphorylated ne hexokinase kusvika ku 2DG-6-phosphate, iyo isingagoni kuve kure nemetabolized ne glycolysis. saka, 2DG inogona kukwikwidzana inhibit glucose uptake uye glycolysis, iyo ndiyo nhanho yekutanga musimba metabolism.

2. Debaser of autophagy Autophagy is a cellular declination medium iyo inobatsira kuchengetedza cellular homeostasis nekudzorera mapuroteni akakuvadzwa kana asingadiwi uye organelles. 2DG induces autophagy nekudzivisa mammalian target yerapamycin (mTOR) nzira, zvichiita kuti kushandiswa kwemajini ane chokuita ne autophagy.

3. Radiosensitizer: Masero eCancer ane glucose yakakwirira uye glycolytic flux kupfuura masero akajairwa, anozivikanwa seWarburg effect. Naizvozvo, 2DG inogona kusarudza kusimudzira maseru egomarara kune radiotherapy nekudzivisa glycolysis uye kuwedzera cellular kusagadzikana mhinduro.

4. Kugadziridza chiitiko cheurodegenerative mamiriro 2DG yakaratidzwa kuti inonatsiridza cognitive basa uye kuderedza neuropathology mumhando dzemhuka dzekunyunyuta kweAlzheimer uye kunyunyuta kwaParkinson. Izvi zvinogona kukanganisa kubva mukusimudzirwa kweglucose metabolism muuropi, kuderedza neuronal kuzvimba uye oxidative kusagadzikana.

5. Chishandiso che metabolic labeling Nekuda kweglucose-yakaita sechimiro uye kugona kubatanidza kuita glycolysis, Purogiramu inonzi 2-deoxy-d-glucose inogona kushandiswa semucherechedzo wemetabolism yekudzidza iyo metabolic fate yeglucose-yakaderedzwa motes mumaseru uye apkins.

Mukupfupisa,2-deoxy d glucose ine mabasa akawanda akakosha mukutsvagisa kwesainzi, anosanganisira se inhibitor ye glycolysis, inducer of autophagy, radiosensitizer, mukana wekurapa wehosha dze neurodegenerative, uye chishandiso che metabolic labeling. Zvishandiso zvaro zvine zvazvingaite kune zvese zvekutanga sainzi uye mushonga wekiriniki.

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In mhedziso

Muchidimbu, senyanzvi 2-Deoxy-D-glucose hupfu mugadziri, isu tine tekinoroji yepamberi, mukana wekuyeresa, iwo emhando yepamusoro, akapfuma ekugadzira ruzivo, uye akanakisa masevhisi. Aya mabhenefiti achaita kuti ive pachena mumakwikwi emusika uye kuhwina kuvimba kwevatengi uye rutsigiro.

Kana iwe uchida kuziva zvakawanda nezve 2-DG kana unofarira kuitenga, unogona kutibata chero nguva. Tichakupindurai nekukasika mushure mekuona meseji.

ruzivo rwedu rwekusangana:

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