Chii chinonzi Acitretin API?

Purogiramu inonzi Acitretin, mushonga unogadzirwa kubva ku vitamin A, inozivikanwawo se-all-trans retinoic acid kana betarretin A. Inodzora kuti vangani masero eganda anowedzera uye anosiyanisa uye anokanganisawo kuti stratum corneum inokura sei. Inonatsiridza kusagadzikana senge keratosis, inoderedza mburwa, uye inodzora ganda pigmentation nekubatanidza kune vhitamini A asidhi receptor mumukati wemasero uye kushandura gene kunyorwa uye mapuroteni kutaura. Iine molecular weight ye 326.43 g / mol uye chimiro chemakemikari yeC21H26O3, Inowanzotora fomu yekrisiti yero kana crystalline powder. Iyo ine nhamba yeCAS 55079-83-9. Hexane inogona kushandiswa kuiomesa, uye nzvimbo yayo yekunyunguduka i228 - 230 °C. Iyo LD50 ne intraperitoneal jekiseni inotangira> 4000 mg/kg(zuva 1) kusvika 700 mg/kg(mazuva gumi nemazuva makumi maviri), maererano nekuongorora kune acute toxin mumakonzo. Iyo inoshanda metabolite ye tretinoin inonzi acitretin, inogadzirwa inotapira inoenderana nevhitamini A. Pamusoro pemamwe mamiriro eganda, inoshandiswa kurapa yakanyanya psoriasis uye keratosis.

Basic Information 

Zita rechigadzirwa: Acitretin

CAS: 55079-83-9

MF:C21H26O3

MW:326.43

EINECS: 259-474-4

MDL Nhamba:MFCD00866632

Kunyungudika:228-230°C

Poindi yekuvira:404.46°C (yakaomarara fungidziro)

Density 1.1348 (yakashata fungidziro)

refractive index 1.4700 (kufungidzira)

kuchengetedza temp. -20°C

Kugadzikana: Kugadzikana

Structural fomula:

Quality standard 

Basa & Kushanda

Purogiramu inonzi Acitretin mushonga wemuromo weboka retinoid remishonga. Inonyanya kushandiswa kurapa akasiyana eganda mamiriro, kunyanya akanyanya psoriasis (yakanyanya plaque psoriasis), keratinization kusagadzikana, uye palmoplantar keratoderma.

Inotevera rondedzero yekushandiswa kwayo uye mabasa:

• Psoriasis kurapwa: inoderedza kukwenya, kuyera, mavara matsvuku, uye kurwadziwa kwemajoini kwakabatana ne psoriasis. Iyo inodzora kupatsanurwa kwesero uye kuwanda, izvo zvinoderedza zvakanyanya keratinization uye kuzvimba kuita uye kuderedza kuoma kwe psoriasis.

• Kurapa kwekeratinization kusagadzikana: inogona kushandiswa kurapa loricrin keratoderma uye isiri-epidermolytic palmoplantar keratoderma. Zviratidzo uye kutarisa kweganda kunovandudzwa nekuderedza kuwandisa kweganda keratinization.

• Kurapa palmoplantar keratoderma: inogona kurapa palmoplantar keratoderma nekudzikisa ukobvu uye mwero wekeratinization muzvanza nezvigadziko, kuderedza zviratidzo marwadzo akadai, fissures, uye kuwedzera keratinization.

Inogona kukonzera mhedzisiro panguva yekurapa, senge muromo wakaoma, cheilitis, zviratidzo zvemaziso, uye kuchinjwa kwechiropa kushanda, saka zvakakosha kuti uzive izvi. Somugumisiro, inofanira kushandiswa pasi pekutariswa kwechiremba, nekuongororwa kunoenderera mberi kwekushanda kwayo nekuchengeteka. Hazvikurudzirwe zvakare kushandiswa nevakadzi vari kutarisira kana kuyamwisa nekuti zvinogona kukuvadza chibereko kana vacheche.

Kuchinja kwakashata

Miromo yakaoma, cheilitis, angular stomatitis, yakaoma kana kushatirwa mucosa yemuromo, uye transitional epithelium zviratidzo zvehuwandu hwevhitamini A. Kusashivirira kubata lenzi, keratitis, cornea ulceration, uye conjunctivitis. zviratidzo zvekuzvimba kwematumbo. nyota uye dikita. kurasikirwa kwebvudzi kunogadziriswa. ganda rakatetepa uye rine makwapa. Paronychia, kusajairika kwembambo kukura, granuloma, uye dzimwe nguva skeletal, majoini, uye tsandanyama kurwadziwa. yakaderera high-density lipoprotein, yakawedzera triglycerides uye cholesterol, yakakwirira transaminases uye alkaline phosphatase. Kuwedzera intracranial pressure zviratidzo zvinosanganisira kutemwa nemusoro, kusaona zvakanaka, kuwandisa calcification, extraosseous calcification, osteoporosis, uye kutanga epiphyseal plate kuvhara.

Production nzira

4-methoxy-2,3,6-trimethylbenzaldehyde (Ⅰ) uye ethyl formate inobata mu phosphoric acid-ine ethanol kuti ibudise musanganiswa (Ⅱ) ine goho re84%. Zvadaro, inopindirana ne (Ⅲ) mu ethyl acetate ine zinc chloride kuti ibudise musanganiswa we6: 4 (E) - (Ⅳ) uye (Z) - (Ⅳ), ine goho rose re83%. Kubvisa asidhi kunopa 27% ye(E,E)-(V) uye 21% ye(Z,E)-(V). (E,E)-(V) inopindirana neacetone mumushonga wemethanol-mvura kuburitsa 25% yekomboni (Ⅵ). Inopindirana ne ethoxyyethynylmagnesium bromide Grignard reagent mu ether kuti ibudise musanganiswa (Ⅶ) ine goho re48%. Pakupedzisira, hydrolysis inobereka 91% chigadzirwa.

Kugadzikana & kuchengetedza

Inobva pavhitamini A asidhi. Kugadzikana kwayo uye kuchengetedza mamiriro akaita seanotevera:

Kugadzikana: Inogona kunge yakagadzikana kwenguva yakareba kana yakachengetwa munzvimbo yakaoma, yakadzivirirwa, uye yakavharwa. Zvisinei, inonzwa kuchiedza uye inogona kuderedza nyore nyore uye kurasikirwa nekubudirira kana yaiswa pachiedza. Pamusoro pezvo, Iyo inonzwawo kune yakanyanya tembiricha uye oksijeni, iyo inogona kuderedza kugadzikana kwayo.

Mamiriro ekuchengetera: Kuti ive nechokwadi chekugadzikana kwayo, anotevera ekuchengetedza mamiriro anokurudzirwa:

• Tembiricha: Zvichengete patembiricha yemumba (15°C -30°C).

• Humidity: Chengetedza mwero wehunyoro hushoma uye dzivirira nzvimbo dzine mwando.

• Chiedza: Chiise mumidziyo inodzivirirwa nechiedza kudzivirira kutarisana nechiedza.

• Packaging: Shandisa midziyo yakavharwa kana zvinhu zvekurongedza kuti uve nechokwadi chekuisa chisimbiso.

Kurongedza & Kutumira

Apex 1kg/foil bag;5kg/carton;25kg/fiber dhiramu;kana kurongedza sechikumbiro chako.

Customization:Customized logo; Customized kurongedza; Graphic customization

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Mutengo wepamberi: yakaderera MOQ nemutengo wemakwikwi;

Quality certification: ISO; Halal; Kosher certified

Mushure mekutengesa sevhisi: Professional timu 7 * 24 maawa sevhisi yevatengi.

In mhedziso

Muchidimbu, senyanzvi Purogiramu inonzi Acitretin mugadziri, isu tine tekinoroji yepamberi, mukana wekuyeresa, iwo emhando yepamusoro, akapfuma ekugadzira ruzivo, uye akanakisa masevhisi. Aya mabhenefiti achaita kuti ive pachena mumakwikwi emusika uye kuhwina kuvimba kwevatengi uye rutsigiro. kana uchiida, pls inzwa wakasununguka kutibata nesu chero nguva. tichakupindura nekukurumidza.

ruzivo rwedu rwekusangana:

E-mail: sales@yihuipharm.com

Tel: 0086-29-89695240
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