Chii chinonzi Actinomycin D?

Actinomycin D, inozivikanwawo seDactinomycin kana Actinomycin, ndeimwe yemishonga inonyanya kukosha yepeptide mukirasi ye actinomycin insulated kubva kuStreptomyces bacteria set up insoil.Iyo yakanyanya hygroscopic brilliant red crystalline powder iyo zvishoma nezvishoma inorasikirwa nekushanda kana ichiratidzwa chiedza. Yaive imwe yekutanga chemotherapeutic agents, uye yanga ichishandiswa kwenguva yakareba. Yakanga iri yekutanga mishonga inorwisa mabhakitiriya ine zvinhu zvegomarara kuwanikwa nevanhu. SelmanA. Waksman nemumwe wake H.B. Woodruff akatanga kuiwana muna 1940. Dactinomycin yakaiswa pachikumbiro cheMerck pasi pezita rechiratidzo Cosmegen mushure mekupihwa mvumo neAmerican FDA musi wa10 Zvita, 1964. yakaratidzwa muzvidzidzo zvebiology yecellular kudzvanyirira kudzokorora. Iyo inokwanisa kusunga kuDNA panguva yekumisikidzwa kwekare, ichigadzira yakaoma ine DNA uye kugaya iyo RNA polymerase kugona kugadzira RNA. Iyo ine simba rekusunga kune yakapetwa kaviri DNA, iyo inoibvumira kudzvanya RNA chigadzirwa pamwe nekuve nekukanganisa pakudzokorora kweDNA. zvakadaro, masayendisiti anowanzo shandisa zvimwe zvipingamupinyi zveDNA, zvakafanana nehydroxyurea, iyo inonyanya kukodzera kushandiswa kwerabhoritari. Mukutsvaga kunosanganisira inflow cytometry uye bitsy kudzidza kwemasero, Actinomycin D powder uye kubuda kwayo kwefluorescent, 7- aminoactinomycin D (7- AAD), inoshandiswa semarara.

Iwo akanyatsokodzera kunyorwa kweDNA nekuda kwehukama hwavo hweGC-rich DNA zvikamu. Sezvo 7-AAD inogona kunamatira kune imwechete-yakasungwa DNA, inobatsirawo pakuona sero apoptosis uye kuudza maseru mapenyu kunze kweafa.

Basic Information

Zita rechigadzirwa: Actinomycin D

Rimwe zita: Actinomycin D, Actinomycin IV, Actinomycin C1, Dactinomycin;Actactinomycin A IV;actinomycin7;actinomycinaiv

CAS:50-76-0

MF:C62H86N12O16

MW:1255.42

EINECS: 246-818-3

Nzvimbo yekunyunguduka: 251-253 ℃

Solubility: ethanol, DMSO: Yakagadzikana mune aqueous mhinduro pa 2-8 ℃ soluble

kuchengetedza temp. 2-8℃

Kugadzikana: Kugadzikana

Structural fomula:

Quality standard

basa

Actinomycin D  ine maitiro akawanda:

1. Anticancer effect:Mushonga unorwisa gomarara wekutanga une maitiro ekudzivirira kenza kuwanikwa nevanhu ndeye actinomycin D. Unosunga kuDNA uye unodzivirira RNA polymerase kubva pakugadzira RNA, ichidzivirira excrescence cells kubva pakuwanda nekuwedzera.

2. Anti-kuzvimba mhedzisiro: ine ananti-kuzvimba mhedzisiro nekuvharidzira mhinduro dzekupandukira uye nenjodzi system yekuedza. Izvi zvinodzikisira kuburitswa kwevanoreverera uye zvinoderedza zviratidzo zvine chekuita nekuzvimba uye kukuvara kwetauro.

3. Immunosuppressive effect: ine immunosuppressive kukanganisa nekudzikisa kuwanda uye kushanda kwemasero ari munjodzi uye nekuvharidzira kugona kwesimba rekudzivirira kuburitsa masoja ekudzivirira chirwere. Mune immunosuppressive remedy inotevera organ transplantation, inoshandiswa.

4. Antiviral effect: ine antiviral properties inoita kuti ishande kune chaiwo mavhairasi. Inogona kumisa kupararira uye kuwanda kwemavhairasi.

5. Antibacterial effect: ine antibacterial chiito chinoshanda chinopesana nemamwe ma microorganisms. Iine simba rekumisa kukura kwebhakitiriya uye kuderedza.

Chakakosha kudzosera kumashure kuti Mushonga unokosha uye unofanirwa kushandiswa chete pasi pekutarisa kwe croaker uye nekuchenjerera. Kuvimbisa kuchengeteka uye kushanda zvakanaka, lozenge uye maitiro ekutonga anofanira kusarudzwa zvichienderana nemamiriro akasiyana.

kunyoresa

Zvikumbiro zve Dactinomycin dzinosanganisira:

1. Anticancer therapy: Yekutanga-mutsara chemotherapy drug actinomycin D inogara ichishandiswa mumakiriniki kurapa akasiyana siyana egomarara, kusanganisira yevana yakasimba excrescences, Wilms excrescence, rhabdomyosarcoma, uye hepatocellular melanoma.

2. Immunosuppressive therapy: inoshandiswa mukugadzirisa immunosuppressive mushure mekusimwa kwenhengo nekuti inokwanisa kuvharidzira iyo isina njodzi system. Inowedzera huwandu hwekubudirira kwekusimwa uye zvinobatsira mukudzikisa mhinduro yekuramba kune nhengo dzakapihwa.

3. Zvirwere zvinotapukira: iyo inorwisa-kuzvimba mitengo inoita kuti ive yakakodzera kurapwa kwemamwe mamiriro ekumukira, anosanganisira rheumatoid arthritis uye seditious bowel kunyunyuta.

Izvo zvakakosha kuti uzive kuti Inogona kukonzera mhedzisiro yakaipa senge kusashanda kwechiropa, matambudziko emudumbu, uye kudzvanywa kwemwongo. Naizvozvo, usati waraira Actinomycin-d, nyanzvi dzezvokurapa dzinoongorora zviratidzo zvemurwere uye dzinogadzira zvirongwa zvekurapa zvakasiyana zvichienderana nemamiriro avo akasiyana. Zvakakosha kushandisa Actinomycin D pasi pekutariswa nachiremba uye kuteerera kurudziro yavo nematanho ekuchengetedza.

Kugadzikana uye kuchengetedza

Kugadzikana uye kuchengetedza mamiriro ayo ndeaya anotevera:

1. Tembiricha yekuchengetera: Kuti ichengetedze kugadzikana kwayo, inofanirwa kuchengetedzwa patembiricha yechando (-20 degrees Celsius). Inogona kutorwa seyakachengetwa kunyange yakadzika tembiricha yekuchengetedza kwenguva refu, yakadai -80 degrees Celsius.

2. Kudzivirirwa kwechiedza: inofanirwa kuchengetwa mumamiriro ezvinhu anoidzivirira kubva kuchiedza uye kugara kunze kwezuva rakananga nekuda kwekunzwa kwayo kuchiedza. Kuderedza kukanganiswa kwechiedza pamushonga, opaque kana midziyo yakasviba inogona kushandiswa kuchengetedza.

3. Nzvimbo yakaoma: Kuchengetedza hunyoro kubva pakukanganisa mushonga, hunofanirwa kuchengetwa munzvimbo yakaoma. Kuti uve nechokwadi chekuti mushonga wacho wakaoma, midziyo yakavharwa kana zvinhu zvekurongedza zvinogona kushandiswa.

4. Dzivisa kutonhora-kunyungudika kutenderera: inogona kudzikama nekudzokororwa kwechando-inonyunguduka, saka zviri nani kudzivirira kuzviita kakawanda usati washandisa.

Ndapota cherechedza izvozvo Actinomycin dmso inofanira kuchengetwa mumamiriro ezvinhu ataurwa kuti ichengetedze kugadzikana kwayo uye kushanda kwayo. Ongorora chimiro chemushonga uye zuva rekupera nguva usati washandiswa.

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In mhedziso

Muchidimbu, senyanzvi Actinomycin D mugadziri, isu tine tekinoroji yepamberi, mukana wekuyeresa, iwo emhando yepamusoro, akapfuma ekugadzira ruzivo, uye akanakisa masevhisi. Aya mabhenefiti achaita kuti Dactinomycin yedu imire mumakwikwi emusika uye kuhwina kwakawanda kuvimba kwevatengi nerutsigiro. kana uchida Actinomycin D poda, pls inzwa wakasununguka kutibata nesu chero nguva. tichakupindura nekukurumidza.

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