Isu tinopa 5- Azacytidine API

Tinodada kupa 5- Azacytidine API, chikamu chepamusoro chemishonga chinoshandiswa seantineoplastic uye antiviral agent. Iyi API inonyanya kushandiswa mukurapa acute myeloid leukemia, myelodysplastic pattern, uye tsika yemyelomonocytic leukemia. Chigadzirwa chedu chinogadzirwa mukuteerana nemaitiro akasimba emhando, icing kuchena kwayo uye kushanda. Inowanikwa mumhando dzepakeji saizi kuti ienderane nemamiriro ako chaiwo. Vimba isu kuti tikupe iwe nesimba rakavimbika uye rinoshanda re5- Azacytidine. taura nesu nguva kuti udzidze zvimwe nezve chigadzirwa ichi uye kuti tingakubatsira sei.

Chii chinonzi Azacytidine?

5- Azacytidine powder, inozivikanwawo seAzacitidine kana 5- AC, ikemikari. Iyo nucleoside analogi yakagadzirwa neadenine base uye chigamba chakaita semhete chakasarudzwa nitrogen heterocycle ine nitrogen. IDNA methyltransferase asset uye inogara ichishandiswa kurapa myelodysplastic pattern(MDS), chirwere cheropa.Zita remakemikari aro 4- Amino- 1-(- D- ribofuranosyl)(1H)- imwe, uye nhamba yayo yeCAS i. 320-67-2. Mushonga wayo wemakemikari ndeye C8H12N4O5, uye huremu hwayo hwemamorekuru i244.2 g/ spook. Inogona kushandura gene expression uye kuve nekugadzirisa mabhenefiti mumamiriro ezvinhu senge myelodysplastic pattern(MDS) nekusnooping neDNA methylation process. Nekurambidza DNA methylation shanduko, inosimudzira kukura kweane hutano hematopoietic masero uye inodzosera kumashure kuumbwa kweasina kukwana hematopoietic masero.

Kuwanikwa kwe5-Azacytidine kuwanikwa kunotangira kuma1950s. Mhedziso yezviwanikwa zvayo inogona kuwanikwa pano:

wokutanga Purogiramu inonzi Azacytidine conflation yakaitwa muna 1958 nevanoedza kubva kuChemical Development Section yeNational Institutes of Health muUnited States. Vakamisa kuti chinhu ichi chinodzivisa methylation yemasero eDNA.

Sangano reNational Cancer Institute (NCI) muUnited States rakatanga kuita ongororo patsva azacytidine muna 1964.

Azacitidine powder yakapfuura kuongorora kutsva nekusimudzira mumakumi emakore apfuura. Iyo US Food and Drug Administration (FDA) yakapa Azacytidine (yakadzokororwa zvakare seVidaza) chikomborero muna 1985 yekushanda kwepamusoro-kutyisidzira myelodysplastic pattern (MDS). Nekuda kweizvozvo, yagara ichishandiswa kurapa MDS zvakare.

Basic Information

Product Name: 5-Azacytidine
CAS:320-67-2
MF:C8H12N4O5
MW:244.2
EINECS: 206-280-2
MDL Nhamba:MFCD00006539
Kuchena: 99%
Kugadzikana: Yakagadzikana kwemakore maviri
solubility: Soluble muDMSO (kusvika 25 mg/ml), kana mumvura (kusvika 12 mg/ml).
Application: Mushonga giredhi kana kushandiswa kutsvaga.
Packing: Sekukumbira kwako
Kuchengetedza: Tembiricha yemumba.
Structural fomula:

Kunyungudika: 226 kusvika 232 ℃

Poindi yekubikira: 534.5 ℃

Kunyungudika kwemvura: soluble

Density: 2.08 g/cm ³

Chinopenya: 277 ℃

Quality standard

Kurongedza: 500g / bhegi; 1kg / bhegi

Mamiriro ekuchengetedza: -20 ℃, hunyoro-huchapupu, hwakavharwa, uye humbowo hwakareruka

Mamiriro ekufambisa: 2-8 ℃ chekufambisa

Category: Chepfu

Toxicity classification: ine chepfu zvakanyanya

Acute toxicity: Oral LD50 mumakonzo: 572 mg / kg; Abdominal cavity mouse LD50: 68 mg/kg

Kupisa kwengozi maitiro: zvinopisa; Kupisa kunoburitsa muchetura wenitrogen oxide utsi; Migumisiro yemishonga kune varwere: kusvotwa, kurutsa, manyoka, uye kuderera kwemasero machena eropa

Kudzimisa mumiriri: hupfu hwakaoma, furo, jecha, kabhoni dhaikisaidhi, mvura yeatomi

Chii kunyoresa ye5-Azacytidine poda ?

Izvi zvinotevera zvinoshandiswa zvakanyanya zve 5-Azacytidine poda uye nzvimbo dzayo dzekushandisa:

1.Antimetabolic drugs

Chiratidzo chikuru ndeye acute myeloid leukemia iyo isingashande pakurapa kwakajairika. Inoshandiswawo kune kenza yemazamu, melanoma, kenza yemukati, etc. Kuratidzwa kukuru kwehupfu ndeye leukopenia, thrombocytopenia, uye kupererwa neropa. Kusvotwa uye kurutsa zvinhu zvinowanzoitika, izvo zvinogona kuvandudzwa nekuiswa kwenguva refu kana kushandisa antiemetics maawa 24 kusvika 48 usati warapwa. Zvimwe zvinokuvadza zvinosanganisira manyoka, neuromuscular disorders, fivha, hypotension, uye rash. Iyo yakagadzirwa ichangobva kugadzirirwa maawa 3-4 isati yashandiswa.

2.A yakasimba kukura inhibitor uye cytotoxic agent

Kudzivirirwa kweDNChemicalbookA methyltransferase, nzira yakakosha yekudzora maitiro ekutaura kwegene, activation, uye kunyarara; Zvishongedzo zvegomarara zvine simba rekurwisa muviri (Gram positive); Inoshandiswa kudzidza mhedzisiro yeDNA yekubatanidza mamorekuru panguva yeDNA methylation process

3. Inogona kukura inhibitory factor uye cytotoxic carrier

Inhibiting DNA methyltransferase, inova yakakosha kudzora nzira yejini kutaura, gene activation, uye gene shutdown. Ichi chinhu chinokonzeresa DNA demethylation kana semi demethylation, zvichibvumira zvinyorwa zvinyorwa kuti zvisunge kuDNA uye kudzoreredza tumor suppressor genes.

Chengetedzo ruzivo

Dangerous goods label: T

Njodzi chikamu kodhi: 45-46-22

Safety instructions: 53-22-36/37/39-45

WGK Germany: 3

RTECS nhamba: XZ3017500

F: 10-23

Tsika yekodhi: 29349990

Chepfu Data: 320-67-2

Toxicity: LD50 mumakonzo (mg / kg): 115.9 ip; 572.3 Nemuromo (Palm, Kensler)

Pharmacological action

Azacytidine Inoshandisa anti-bundu mhedzisiro nekudzikisa DNA methylation uye kushandisa yakananga cytotoxicity pamapfupa emapfupa abnormal hematopoietic masero. In vitro zvidzidzo zvakaratidza kuti kusungirirwa kwechigadzirwa ichi pahupamhi inhibition yeDNA methylation haidzivisi zvakanyanya DNA synthesis. Chiitiko cheyakaderera methylation chinogona kudzoreredza basa rakajairwa remajini zvine hukama zvakanyanya nekusiyanisa uye kuwanda kwemabhuku emakemikari akanaka. Iyo cytotoxic mhedzisiro yechigadzirwa ichi inogona kukonzera kufa kwemasero ari kukurumidza kuwanda, kusanganisira maseru egomarara akarasikirwa neyakajairwa maitiro ekugadzirisa, nepo masero asina kuwedzera asina hanya nechigadzirwa ichi. Muchidimbu, physicochemical properties, nzira dzekugadzirira, pharmacological madhara, uye kushandiswa kweazacitidine

Chazvakanakira Our

Zvakapfuma ruzivo: tine 13 Makore ehunyanzvi ruzivo;

Vatengi pasi rese: tengesa kune dzinopfuura 100 nyika;

Ipa zvigadzirwa zvakasiyana-siyana: zvigadzirwa zvakaiswa kune ese makuru epasi rose mhando muminda yemishonga, chikafu chekuwedzera, zvekuzora, chikafu chemhuka uye chinoshanda chikafu.

Mutengo wepamberi: yakaderera MOQ nemutengo wemakwikwi;

Quality certification: ISO; Halal; Kosher certified

Mushure mekutengesa sevhisi: Professional timu 7 * 24 maawa sevhisi yevatengi.

Muchidimbu, senyanzvi Azacitidine API mugadziri, isu tine tekinoroji yepamberi, mukana wekuyeresa, iwo emhando yepamusoro, akapfuma ekugadzira ruzivo, uye akanakisa masevhisi. Aya mabhenefiti achaita kuti ive pachena mumakwikwi emusika uye kuhwina kuvimba kwevatengi uye rutsigiro.

ruzivo rwedu rwekusangana: 

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Tel: 0086-29-89695240
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