ABT-530

Pibrentasvir (ABT-530) CAS: 1353900-92-1
Kuonekwa: Muchena kusvika Pale Yellow powder
standard: mumba
Mucherechedzo: YIHUI
Kutakura: 1g; 10g; 100g
Kugovera Mano: 1000g pamwedziSherufu Hupenyu: Makore maviri
Chikumbiro: Lab research
Kubhadhara: T/T, LC kana DA
Muenzaniso: iripo
Nguva Yekutumira: Yakagadzirira Stock muNharaunda Warehouse, mazuva 1-3
Kurumidza uye Kuchengetedza Kutumira
Origin: China
Kutumira: DHL, FedEx, TNT, EMS,Negungwa,Nemhepo
Certifications: ISO9001, ISO22000, HACCP, HALAL, KOSHER
Haikwanisi kutengesera vanhu
  • Fast Delivery
  • Quality Panga
  • 24/7 Vatengi Sevhisi
Product Introduction

Nhanganyaya yeAbt-530 neYihui Pharmaceuticals:

Munzvimbo ine simba yemakemikari emuindasitiri, Yihui Pharmaceuticals inodada inosuma chigadzirwa chayo chemureza, Abt-530, mhinduro yekucheka-kumucheto yakagadzirirwa kusangana nezvinodiwa zvakasiyana zvemaindasitiri akasiyana. Senyanzvi yekugadzira uye mutengesi, Yihui Pharmaceuticals inoomerera kune dzimwe nyika zviyero, kuve nechokwadi chepamusoro-notch mhando ine zvitupa zvakaita se ISO, Kosher, Halal, uye GMP.

1. Chigadzirwa Mhedzisiro:

Abt-530, musanganiswa wemakemikari, wakagadzirwa zvine hungwaru kuti uenderane nezvinodiwa zvakaomarara zvemaindasitiri akawanda. Ichi chigadzirwa chine chimiro chakasiyana chinochisiyanisa kubva kune zvakajairika dzimwe nzira. Yihui Pharmaceuticals, nekuzvipira kwayo kuita zvakanaka, inoiratidza sechigadziro chepasi chine humbowo husingaenzaniswi.

Abt-530 ibhuku, rinodzorwa nemuromo, diki diki inhibitor yeBruton's tyrosine kinase (BTK) kemikari. Iri kugadzirwa neYihui Mishonga yekurapa kweakasiyana B-cell malignancies, kusanganisira inogara lymphocytic leukemia (CLL), mantle cell lymphoma (MCL), uye Waldenström's macroglobulinemia (WM).

BTK chinhu chakakosha chemureza muB-cell receptor (BCR) nzira, iyo inotora chikamu chekukurumidzira mukumisikidzwa, kupatsanurwa, uye kutsungirira kweB masero. Abt-530 inosungirirana uye inodzvanya chiito cheBTK, zvichitadzisa BCR mureza nzira uye zvichikonzera chipingamupinyi cheB-cell kuwedzera uye kutsungirira.

Abt-530 yakaongororwa mune akati wandei miedzo yekiriniki mune varwere vane B-cell malignancies. Muchikamu chechikamu chechipiri chekuedza kune varwere vane CLL yakadzokororwa kana kuti refractory, Abt-530 yakaratidza huwandu hwekupindura (ORR) hwe80%.


Ruzivo rwekutanga:

Zita reChigadzirwa: ABT-530

CAS: 1353900-92-1

MF:C57H65F5N10O8

MW:1113.18

EINECS: 829-351-5

MDL Nhamba:MFCD30747902

Kuchena: 98%+

Package: 1g, 10g, 25g, 500g

Inoshandiswa: tsvagiridzo uye pharma giredhi

Kugadzikana: Kugadzikana

Structural fomula:

1353900-92-1.webp

Specification:

Items

                       Standard

                              mugumisiro


tsananguro


Kunze-chena kusvika kuchena hupfu hwakasimba


Yakachena yehupfu yakasimba

kuongorora

H-NMR

HPLC nguva yekuchengetedza

Inoenderana

Inoenderana


purity

99.0%Maminitsi

99.64%

Chrial kuchena

99.0%Maminitsi

99.96%

KURASIKA PAKUOMESA

1.0% Max

0.25%

Gara patsva

0.5% Max

0.32%

Mamiriro ekuchengetedza

TENGA PACHINOtonhorera UYE PAKASVA DVISA CHIEDZA.

Chiverengwa

Inoenderana ne ENTERPRISE STANDARD

2. Basa uye Tsananguro Yebasa :

Basa iboka rezvikwereti, zvinosungirwa, uye fungidziro zvine chekuita nechinzvimbo kana basa. Inotaridza chikonzero chechinzvimbo uye mabasa anofanirwa kuitwa kuzadzisa zvinangwa zvesangano.

Kugona (a capability in English) ibato rakati kana basa rinoitwa sechikamu chebasa. Chimwe chikamu chebasa chine mwero chinowedzera pakuitwa kwese kwezvinangwa zvebasa.

Mabasa nemabasa zvine hukama hwakasimba. Basa rinoitwa kubva muboka remabasa asingaperi anoitwa kugutsa basa. Zvinhu zvebasa zvinowanzoenderana nezvinangwa nezvinangwa zvesangano. Vanobatsira kuona kuti vashandi vanonzwisisa mabasa avo uye zvavanotarisira.

  • Vanofambisa kutaurirana kwakanaka uye kubatana mukati mezvikwata.

  • Vanopa hwaro hwekuongororwa kwekuita nekusimudzira.

  • Vanobatsira kuenzanisa mabasa ega ega nezvinangwa zvesangano zvakazara uye zvinangwa.

Mabasa nemashandiro ndiwo mazwi akakosha muhurongwa nekugadzira kwesangano. Basa rakajeka uye tsananguro yebasa zvakakosha pakuita basa rinobudirira, kubatana kwechikwata, uye kubudirira kwesangano.

Abt-530 inogadzirwa kuti ibudise kuita kwakasiyana-siyana pane dzakasiyana siyana maapplication. Basa rayo rakasiyana-siyana rinosanganisira Chigadzirwa ichi chinomira sechiratidzo chekuzvipira kweYihui Pharmaceuticals kupa mhinduro itsva dzinopa simba maindasitiri pasi rese.

3. Synthesis Maitiro Tsananguro :

The synthesis ye Abt-530 zvinosanganisira maitiro akaomarara anosanganisa yekucheka-kumucheto tekinoroji nechaiyo nzira. 

Abt-530 ndeyekugadzira diki molecule inhibitor yeBruton's tyrosine kinase (BTK). Iyo inogadzirwa kuburikidza neakawanda-nhanho maitiro ayo anosanganisira akati wandei emakemikari maitiro uye matanho ekuchenesa.

Matanho Akakosha muSynthesis yeAbt-530:

  • Kugadzirira kwekutanga zvinhu:Iyo synthesis inotanga nekugadzirwa kwezvinhu zvakasiyana-siyana zvekutanga, zvinosanganisira: 4-Bromo-2-fluoroaniline.

  • Suzuki Coupling Reaction:Nhanho yekutanga mukuumbwa ndeye Suzuki coupling reaction pakati pe4-bromo-2-fluoroaniline uye 2-chloro-4-fluoropyrimidine. Kuita uku kunokonzereswa ne palladium catalyst uye inoumba biaryl yepakati.

  • Alkylation Reaction:Iyo biaryl yepakati inobva yaiswa alkylated ne 3-aminopyridine uchishandisa alkylating agent. Izvi zvinounza iyo aminopyridine moiety mumorekuru.

4. Product Quality Standards :

Yihui Pharmaceuticals inoomerera kune dzakaomarara mhando zviyero mukugadzirwa kweAbt-530. Kuzvipira kwedu kune zvakanakisa kunoratidzwa mukutevedzera kwedu mabhenji epasi rose, kuve nechokwadi chekuti chigadzirwa chinosangana uye chinodarika zvinotarisirwa nevatengi vedu vanokoshesa. 

Abt-530, sechigadzirwa chemishonga, inofanirwa kusangana neyakaomesesa yemhando zviyero kuti ive nechokwadi chekuchengetedza kwayo uye kushanda kwayo. Aya mazinga akatemerwa nezviremera zvinodzora zvakaita seUS Food and Drug Administration (FDA) neEuropean Medicines Agency (EMA).

  • Kuzivikanwa: Chigadzirwa chacho chinofanira kusimbiswa kuti ndicho uye kwete zvimwe zvinhu zvine hukama kana tsvina.

  • Kuchena: Chigadzirwa chacho chinofanira kunge chine mwero waro wakatarwa uye ive isina tsvina, senge zvinhu zvekutanga, zvepakati, uye zvinosvibisa zvigadzirwa.

  • Potency: Chigadzirwa chacho chinofanirwa kunge chine biological chiitiko chinotarisirwa uye chinosangana nezvakanyorwa zvine simba.

  • Kudzivirirwa: Chigadzirwa chacho chinofanira kunge chakachengeteka kuti chishandiswe uye chinosangana neyakagadzikwa kuchengetedza zviyero. Izvi zvinosanganisira kuongorora zvingangoitika mhedzisiro uye chepfu.

  • Kuramba: Chigadzirwa chacho chinofanira kunge chakagadzikana pasi pemamiriro ekuchengetedza akatsanangurwa uye kuva nehupenyu hunogamuchirwa.

  • Raw Material Testing: Kuedzwa kwezvinhu zvekutanga uye reagents kuve nechokwadi chemhando yavo uye kutevedzera zvakatemwa.

  • In-Process Testing: Kuedzwa kwezvigadzirwa zvepakati panguva yekugadzira nzira yekutarisa kufambira mberi kweiyo synthesis uye kuona chero kutsauka.

  • Yakapera Kuedzwa Kwechigadzirwa: Kuedzwa kwechigadzirwa chekupedzisira kusimbisa kuzivikanwa kwayo, kuchena, potency, kuchengeteka, uye kugadzikana.

5. Nzvimbo dzeMashandisirwo muMaindasitiri Akasiyana :

Abt-530, chinyorwa cheBTK inhibitor chakagadzirwa neYihui Pharmaceuticals, chakaratidza kukwanisa kunovimbisa mukurapa zvirwere zvakasiyana-siyana zveB-cell. Pamusoro pekushandiswa kwayo kwekutanga mune oncology, iri kuongororwa zvakare kune yayo inogona kushandiswa mune mamwe minda:

  • Lead Optimization: Inogona kushanda sechinhu chinotungamira chekugadzirwa kweBTK inhibitors nekuvandudzwa potency, selectivity, uye pharmacokinetic properties.

  • Synergistic Combinations: Inogona kusanganiswa nemimwe mishonga kugadzira misanganiswa yesynergistic yekurapa B-cell malignancies uye kukunda kuramba zvinodhaka.

  • Biomarker Identification: Zvidzidzo pamusoro pemaitiro ayo ekuita uye mhinduro mazinga anogona kubatsira kuziva biomarkers inofanotaura kurapwa kwemhinduro uye kutungamira kusarudzwa kwevarwere.

  • Murwere Stratification: Kushanda kwayo uye kuchengetedza nhoroondo inogona kushandiswa kubatanidza varwere mumapoka akasiyana enjodzi, zvichiita kuti munhu aite nzira dzekurapa.

  • Treatment Monitoring: Kuiongorora mazinga muropa revarwere kunogona kubatsira kukwenenzvera dosing regimens uye kuve nechokwadi chekurapa kwakanaka.

  • Shamwari Diagnostics: Kuvandudzwa kweanofambidzana naye diagnostics kunogona kubatsira kuona varwere vangango batsirwa neAbt-530 kurapwa.

  • Clinical Trials: Ikozvino iri kuongororwa mumakiriniki ekuedzwa kwekurapa kwakasiyana-siyana B-cell malignancies. Miyedzo iyi ine chinangwa chekuongorora kuchengetedzeka kwemushonga, kushanda kwayo, uye kurongeka kwemushonga.

  • Patient Registries: Dhata kubva kwairi miedzo yekiriniki uye kushandiswa kwepasirese kunogona kuunganidzwa mumabhuku evarwere kuti vatarise mhedzisiro yenguva refu uye kuona zvingangove zvinonetsa kuchengetedza.

  • Mvumo yezvinodhaka: Dhata kubva kumakiriniki ekuyedzwa uye preclinical zvidzidzo zvinoshandiswa kutsigira zvinongedzo zvinotumirwa kune mvumo yeAbt-530 munyika dzakasiyana.

  • Post-Marketing Surveillance: Mushure memvumo yeAbt-530, kuenderera mberi kwekutarisa uye kuongororwa kunoitwa kuti ive nechokwadi chekuchengetedza uye kushanda kwayo munzvimbo chaidzo dzepasirese.

Aya minda yekushandisa inosimbisa kugona kwe Abt-530 kupfuura kushandiswa kwayo kwekutanga mune oncology. Kumwe kutsvagisa uye kuedza kwekusimudzira kunogona kuburitsa mamwe maapplication uye kubatsira mukufambisira mberi kweakasarudzika uye anoshanda marapirwo eB-cell malignancies.


6.Kutakura & Kutumira


5 yihui shipping.webpKurongedza:

1kg/foil bag;5kg/katoni;25kg/fiber dhiramu; kana kurongedza sechikumbiro chako.

Customization:

l Customized logo

l Customized kurongedza

l Graphic customization

Kutumira:

By Courier; NeMhepo kana NeGungwa, maererano nezvaunoda








7.Payment Term

6 pay.webp


8. Sei Kusarudza Xi'an Yihui?

Customer feedback

7 Mutengi Comments.webp

Xi'an Yihui zvitupa

8 chitupa.webp

Wkugamuchirwa ku Xi'an Yihui Factory  

9 Factory & Warehouse.webp

Chazvakanakira Our

Zvakapfuma ruzivo: tine 13 Makore ehunyanzvi ruzivo;

Vatengi pasi rese: tengesa kune dzinopfuura 100 nyika;

Ipa zvigadzirwa zvakasiyana-siyana: zvigadzirwa zvakaiswa kune ese makuru epasi rose mhando muminda yemishonga, chikafu chekuwedzera, zvekuzora, chikafu chemhuka uye chinoshanda chikafu.

Mutengo wepamberi: yakaderera MOQ nemutengo wemakwikwi;

Quality certification: ISO; Halal; Kosher certified

Mushure mekutengesa sevhisi: Professional timu 7 * 24 maawa sevhisi yevatengi.




9.Bata Isu:

Yihui Pharmaceuticals inodada nekuva akavimbika Abt-530 mugadziri uye mutengesi. Kuzvipira kwedu kune mhando uye kuenderana kune epasi rose zviyero kunosimbiswa ne ISO, Kosher, Halal, uye GMP certification. Zvekubvunza kana kuisa odha, taura nesu nekukurumidza pa sales@yihuipharm.com.

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