AZD5363

CAS: 1143532-39-1
Kuonekwa: Off-White kusvika Pale Beige powder
Mucherechedzo: YIHUI
Kutakura: 1g; 10g; 100g
Kugovera Mano: 2000g pamwedziSherufu Hupenyu: Makore maviri
Chikumbiro: Lab research
Kubhadhara: T/T, LC kana DA
Muenzaniso: iripo
Nguva Yekutumira: Yakagadzirira Stock muNharaunda Warehouse, mazuva 1-3
Kurumidza uye Kuchengetedza Kutumira
Origin: China
Kutumira: DHL, FedEx, TNT, EMS,Negungwa,Nemhepo
Certifications: ISO9001, ISO22000, HACCP, HALAL, KOSHER
Haikwanisi kutengesera vanhu
  • Fast Delivery
  • Quality Panga
  • 24/7 Vatengi Sevhisi
Product Introduction

Chii chinonzi AZD5363?

Azd5363, chigadzirwa chepamusoro-soro muindasitiri yemishonga uye yekutsvagisa, ikomisheni ine hunyanzvi inozivikanwa nekusiyana-siyana kwekushandisa uye kushanda kunoshamisa. Yakagadzirwa naYihui, mugadziri ane mukurumbira uye mutengesi mumunda, Azd5363 yawana kutariswa kwakakosha nekuda kwehunhu hwayo hunoshamisa uye kuita kwayo.

Azd5363 ibhuku, remuromo bioavailable inhibitor yeBTK ine zvingangodzoreredza maapplication mune akasiyana B cell malignancies uye immune system zvirwere. Mushonga wacho unonyanya kutsungirira uye une chimiro chakanaka chehutano. Parizvino iri mukunonoka-danho rekiriniki shanduko yezviitiko, uye zvakajairika kutsigirwa kushambadza munguva pfupi.


Basic Information

Chigadzirwa Zita: AZD5363

CAS: 1143532-39-1

MF:C21H25ClN6O2

MW:428.92

MDL Nhamba:MFCD22628785

Kuchena: 99%

Package: 1g; 5g; 25g; 1kg

Inoshandiswa: pharma giredhi & Lab research

Kugadzikana: Kugadzikana

Structural fomula:

1143532-39-1.webp

Specification Parameter:

Parameterukoshi
Molecular FormulaC21H25ClN6O2
Molecular Weight428.92
KuonekwaMuchena kusvika pachena-poda yakachena
SolubilitySoluble muDMSO, zvishoma mumvura
Purity≥ 99%
chengetedzoChengeta pa -20 ° C

Kemikari Kuumbwa:

chikamuPercentage Composition
Azd5363  99%

Tsanangudzo Yebasa uye Basa:

Azd5363 inoita basa rakakosha mukuvharisa makinase chaiwo, kukanganisa nzira dzakakosha dzezviratidzo zvinosanganisirwa muzvirwere zvakasiyana siyana, kusanganisira mamwe magomarara. Kugona kwayo kusarudza nekunangisa nzira idzi kunoita kuti ive chishandiso chakakosha kune vanotsvaga uye varapi zvakafanana.

Mukutsvakurudza kenza, Azd5363 yakaratidza mhedzisiro inovimbisa nekukanganisa kukura kwebundu maseru uye kudzvinyirira metastasis. Pamusoro pezvo, kushandiswa kwayo kunosvika kune neurodegenerative kusagadzikana, uko kunoratidza kugona mukuderedza pathological maitiro. Kusarudzika kwekomboni yacho kunosimbiswa zvakare muzvidzidzo zvekuzvimba, zvichiratidza anti-kuzvimba zvimiro.

Iyo iBruton's tyrosine kinase (BTK) inhibitor. BTK chinhu chakakosha chemureza muB masero uye macrophage, uye kuzvidzora kwayo kwakaratidzwa kuve nekugadzirisa kungangoita muB cell malignancies akasiyana uye immune system zvirwere. Inosungirirana neATP-inorambidza homwe yeBTK, nenzira iyi ichidzvanya kuita kwayo enzymatic. Izvi zvinokurudzira kudziviswa kwenzira dzekudzika mureza, kusanganisira iyo PI3K/Akt/mTOR uye NF-κB nzira, idzo dzakabatikana nekuvandudzwa kwesero, kutsungirira, uye kupatsanurwa.

Iyo inoverengeka, yemuromo bioavailable inhibitor yeBTK ine zvinogoneka kudzorera mashandisirwo muakasiyana B cell malignancies uye immune system zvirwere. Mushonga wacho unogara kwenguva refu uye une chimiro chakanaka chekugara zvakanaka. Ikozvino wave mukunonoka kuchipatara, uye zvakajairika kuti utsigirwe pakushambadza munguva pfupi.

Synthesis Process Description :

The synthesis ye Azd5363 inzira yakaoma-nhanho yakawanda inosanganisira akati wandei maitiro akakosha. Mucherechedzo wakajeka weiyo synthesis process ndeiyi inotevera:

  1. Kutanga Zvishandiso: Iyo synthesis yeAzd5363 inotanga nekugadzirwa kwezvinhu zviviri zvakakosha zvekutanga: 4-amino-3- (4-fluorophenyl) benzoic acid uye 2-amino-4-methylpyrimidine.

  2. Suzuki Coupling: Danho rekutanga mukugadzirisa ndeye Suzuki coupling reaction pakati pe4-amino-3- (4-fluorophenyl) benzoic acid uye 2-amino-4-methylpyrimidine. Kuita uku kunokonzereswa ne palladium catalyst uye inoumba biaryl yepakati.

  3. Alkylation: Iyo biaryl yepakati inobva yaiswa alkylated ne 1-bromo-3-chloropropane kuti iite alkylated yepakati.

  4. Cyclization: Iyo alkylated yepakati inozofambiswa nebhasikoro kuti iite pyrimidine mhete. Iyi cyclization reaction inowanzoitwa pachishandiswa hwaro hwakasimba, senge sodium hydride.

  5. Acylation: Mhete yepyrimidine inobva yaiswa acylated ne 4-methylbenzoyl chloride kuti iite acylated yepakati.

  6. Suzuki Coupling: Iyo acylated yepakati inozoiswa kune yechipiri Suzuki coupling reaction, panguva ino ine 4-methoxyphenylboronic acid. Kuita uku kunoumba yekupedzisira biaryl yepakati.

  7. Final Cyclization: Iyo yekupedzisira biaryl yepakati inozofambiswa bhasikoro kuumba chigadzirwa chaunoda, Azd5363. Iyi cyclization reaction inowanzoitwa pachishandiswa hwaro hwakasimba, senge sodium hydride.

The synthesis ye Azd5363 Inosanganisira maitiro ane hunyanzvi anovimbisa kuchena uye kushanda kwechigadzirwa chekupedzisira. Kutanga nemhando yepamusoro mbizha, Yihui inoshandisa mamiriro-ye-the-art synthesis matekiniki, achinyatso kudzora maitiro ekuita kuti awane mhedzisiro yakanaka. Maitiro acho anosanganisira akawanda ekuchenesa matanho ekubvisa tsvina, kuvimbisa chigadzirwa chepamusoro chegiredhi remishonga.

Quality Standard Description :

Azd5363's quality zviyero zvinosanganisira zvinotevera zvinhu:

  1. Kuonekwa: Inofanira kunge iri chena kusvika kune-white-white powder kana makristasi.

  2. Solubility: Inofanira kunyungudika mu dimethyl sulfoxide (DMSO) uye ethanol.

  3. Zviripo: Zviri mukati mezvigadzirwa zvinofanirwa kunge zviri pakati pe98.0% ne102.0%.

  4. Tsvina: Izvo zvisina kuchena zviri muzvigadzirwa zvinofanira kunge zvisingasviki 0.5%.

  5. mwando: Hunyoro huri mairi hunofanira kunge huri pasi pe0.5%.

  6. Heavy simbi: Iyo inorema simbi yemukati muAzd5363 inofanirwa kuenderana nezvinodiwa zveICH Q3D gwara.

  7. Microorganisms: Iyo microbial content muAzd5363 inofanirwa kuenderana nezvinodiwa zveUSP <61> uye <62>.

  8. Yakakurumidza kugadzikana kuyedza: Inochengetwa pa40 ℃/75% RH kwemwedzi mitanhatu.

  9. Yenguva refu kugadzikana kuyedzwa: Inochengetwa pa25 ℃/60% RH kwemwedzi mitanhatu.

Migumisiro yekuongorora kwekugadzikana inofanira kuratidza izvozvo Capivasertib yakagadzikana pasi pemamiriro ekuchengetedza.

PaYihui, kunaka kwakakosha. Zvivakwa zvedu zvekugadzira zvinotevedzera zvakaomesesa zvepasirese zviyero, uye zvedu Azd5363 inoitwa kuyedzwa kwakasimba padanho rega rega rekugadzira. Nekuzvipira kuita zvakanaka, Yihui akawana ISO, Kosher, Halal, uye GMP zvitupa, zvichipupurira kutevedza kwechigadzirwa nemhando yepamusoro yeindasitiri. Yedu yemhando yekusimbisa matanho anovimbisa kuti batch yega yega yeAzd5363 inosangana neyakatsanangurwa kuchena uye maitiro ekuita.

Minda Yekushandisa muMaindasitiri Akasiyana:

Azd5363 mushonga mutsva unovimbisa weakasiyana B cell malignancies uye immune system zvirwere. Mushonga unogara uchishingirira une chimiro chakanaka chekugara zvakanaka. Clinical preliminaries dzakaratidza kuti zvinomanikidza mukurapa mamiriro ezvinhu aya, uye kushandura kuita sarudzo yakakosha yekurapa kune varwere vane zvirwere izvi zvakajairika.

Mushonga unoshandiswa kurapa akasiyana siyana e autoimmune mamiriro uye cancers inokonzerwa neB masero. Iyo iBruton's tyrosine kinase (BTK) inhibitor, uye zvinoreva kuti inovharira kuita kweBTK, puroteni inobatikana nenzira dzinoratidzira dzeB masero.

Capivasertib inowana zvikumbiro mumaindasitiri akasiyana siyana, kubva kumishonga kusvika kutsvagiridzo yedzidzo. Muchikamu chemishonga, inoshanda sechinhu chakakosha mukuvandudzwa kwemanoveli ekurapa cancer uye zvimwe zvirwere. Vatsvagiri muacademia vanokwiridzira kinase inhibitory zvivakwa zvekujekesa zvakaomarara masero ekusaina nzira, zvichibatsira mukufambira mberi mune molecular biology.

Kurongedza & Kutumira


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Customization:

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l Graphic customization

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By Courier; NeMhepo kana NeGungwa, maererano nezvaunoda





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Zvakapfuma ruzivo: tine 13 Makore ehunyanzvi ruzivo;

Vatengi pasi rese: tengesa kune dzinopfuura 100 nyika;

Ipa zvigadzirwa zvakasiyana-siyana: zvigadzirwa zvakaiswa kune ese makuru epasi rose mhando muminda yemishonga, chikafu chekuwedzera, zvekuzora, chikafu chemhuka uye chinoshanda chikafu.

Mutengo wepamberi: yakaderera MOQ nemutengo wemakwikwi;

Quality certification: ISO; Halal; Kosher certified

Mushure mekutengesa sevhisi: Professional timu 7 * 24 maawa sevhisi yevatengi.


Taura nesu:

Yihui, senyanzvi Azd5363 mugadziri uye mutengesi, akazvipira kusimudzira zviyero zvepamusoro muindasitiri. Kutevedzera kwedu zvitupa zvepasi rese se ISO, Kosher, Halal, uye GMP kunoratidza kuzvipira kwedu kune mhando yechigadzirwa uye kugutsikana kwevatengi. Zvekubvunza kana kutenga, ndapota taura nesu nekukurumidza pa sales@yihuipharm.com.

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