Exenatide Acetate

CAS: 141732-76-5
Chitarisiko: Muchena kusvika Kuchena-Upfu
Chiyero: 99%
Kushandisa:Drug Peptides & Lab tsvakurudzo
Mucherechedzo: YIHUI
Kutakura: 1g; 10g; 100g
Kugovera Mano: 5000g pamwedzi
Sherufu Hupenyu: Makore maviri
Kubhadhara: T/T, LC kana DA
Muenzaniso: iripo
Nguva Yekutumira: Yakagadzirira Stock muNharaunda Warehouse, mazuva 1-3
Kurumidza uye Kuchengetedza Kutumira
Origin: China
Kutumira: DHL, FedEx, TNT, EMS,Negungwa,Nemhepo
Certifications: ISO9001, ISO22000, HACCP, HALAL, KOSHER
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Product Introduction

Chii chinonzi Exenatide Acetate?

Exenatide acetate chinhu chakareruka cheexendin-4, kemikari yepeptide yakagadzirwa nenhengo dzemate dzechikara cheGila. Iyo glucagon-yakaita peptide-1 (GLP-1) receptor agonist, uye izvo zvinoreva kuti inosungira uye inomisa iyo GLP-1 receptor murwatata. Izvi zvinosimudzira kuuya kwe insulin kubva kumasero e beta, ayo anobatsira nekudzikisa mazinga eglucose.

Basic Information

Zita reChigadzirwa: Exenatide acetate

CAS: 141732-76-5

MF:C186H286N50O62S

MW:4244.60796

EINECS: 1592732-453-0

MDL Nhamba:MFCD08704781

fomu Solid

ruvara White kusvika Off-White

Kuchena: 98%+

Package: 1g; 5g; 25g

Yakashandiswa: Tsvakurudzo yeLab

Kugadzikana: Kugadzikana

Structural fomula:

141732-76-5.webp

Zvinotsanangurwa uye Parameters:

chinhu

Specification

Results

Chimiro

White powder

Conformed

Molecular weight

4186.6±1Da

4186 Da

Kuchena(RP-HPLC)

≥98.5%

99.09%

Kusachena kumwe chete (HPLC)

≤0.5%

0.4%

Kuumbwa kweamino acid

± 10% yezvinyorwa

Inopesana

Peptide content (N%)

≥80.0%

87.5%

Mvura yemukati (Karl Fischer)

≤5.0%

4.8%

Acetate yemukati (HPLC)

≤12.0%

10.6%

Mass Balance

95.0 ~ 105.0%

102.9%

Yambiro: Yekushandisa marabhoritari chete, kwete yekushandiswa nevanhu.

Kemikari Kuumbwa:

Exenatide Acetate, yakarongedzwa kuburikidza nekucheka kumucheto biotechnological process, inogadzirwa kubva kumaamino acids. Kurongeka kwakakosha kunosanganisira alanine, glycine, histidine, leucine, proline, uye serine, pakati pevamwe. Iyo komputa ine pharmacological properties uye kurapa kwakanaka kunowedzerwa nekurongeka chaiko kwemaamino acids. Iyo injinjini yakapusa ye exendin-4, kemikari yepeptide yakagadzirwa nenhengo dzemate dzechikara cheGila. Yakagadzirwa kubva makumi matatu nemapfumbamwe amino acids uye ine sub-atomic resipi yeC39H183N288O42. Iyo sub-atomic mutoro we exenatide acetic acid derivation ndeye 53.

Iyo kemikari chimiro che exenatide acetate yakafanana chaizvo neye exendin-4. Misiyano chete ndeyokuti exenatide acetate ine boka reacetyl rakabatanidzwa kune lysine yakasara panzvimbo ye 28. Iri boka reacetyl rinoita kuti exenatide acetate iwedzere kugadzikana uye inopesana nekuparara nema enzymes.

Exenatide acetate ihupfu huchena kusvika kuchena hunonyungudika mumvura. Iyo inowanzogadzirwa semhinduro yejekiseni.Zviratidzo zvinonyanya kuzivikanwa zveExenatide acetate zvinosanganisira queasiness, spewing, looseness of the bowels, uye kurwadziwa mudumbu. Izvi zvinowanzoitika zvinowanzoitika zvinyoro uye zvinonyangarika mukati mehafu yemwedzi. Zvimwe zvinogona kuitika zvinosanganisira kuneta, dzungu, uye musoro.

Exenatide acetate kurapa kwechirwere cheshuga cherudzi rwechipiri iyo yakachengeteka uye inoshanda. Inogara ichishandiswa musanganiswa nemishonga yakasiyana, senge metformin kana sulfonylureas. Ndiyo imwe yenguva inoshandiswa kurapa kuomarara.

Basa uye Basa:

Inoshandiswa mukurapa chirwere cheshuga cherudzi rwechipiri sezvo inoratidzira maitiro eGLP-2. Nekumisa uye nekumisa iyo GLP-1 receptor, exenatide acetic acid derivation inosimudzira kuuya kwe insulin kubva kumasero e beta, inodzosera kumashure kucheneswa kwemudumbu, uye inomisa nzara. Izvi zvinokanganisa zvinobatsira kudzikisa mazinga eglucose uye kuwedzera kukudziridza kutonga kweglucose.

Exenatide acetate inowanzoshandiswa mukusanganiswa nemishonga yakasiyana, senge metformin kana sulfonylureas. Izvi zviri pazvikonzero zvekuti exenatide acetic acid derivation haisi kumanikidza kudzikisa mazinga eglucose muvanhu vasingabudisi insulin.

Uyezve, kufutisa kunombobatwa neexenatide acetate. Izvi zvinodaro nekuti inogona kunonoka kuburitsa mudumbu uye kudzvanya chishuwo, zvese izvo zvinogona kubatsira vanhu kuderedza uremu.

Basa mukurapa kweChirwere chechipiri chechirwere cheshuga

  • Iyo inodzivirirwa uye inoshanda kurapwa kwerudzi rwechipiri chirwere cheshuga. Inogara ichishandiswa musanganiswa nemishonga yakasiyana, senge metformin kana sulfonylureas. Mukufamba kwemavhiki makumi maviri nemana, zvakaratidzwa kuti exenatide acetate yakaderedza HbA24c mazinga ne1 kusvika 1.0 muzana.

  • Mune zvimwe zviitiko, rinoshandiswawo kurapa kufutisa. Izvi zviri pazvikonzero zvekuti exenatide acetic acid derivation inodzora nzara uye inodzoreredza kubuda mudumbu, izvo zvinogona kukurumidza kuderedza uremu. Mukati memavhiki e24, exenatide acetate yakawanikwa kuderedza uremu hwemuviri neavhareji ye4.5 kilogram.

  • Iyo inodzivirirwa uye inoshanda kurapwa kwerudzi rwe2 chirwere cheshuga uye corpulence. Inoshanda nekutevedzera maitiro eGLP-1, kemikari inogadzirwa nediki digestive system

Exenatide acetate inodzivirirwa uye inomanikidza kurapwa kwerudzi rwe2 chirwere cheshuga uye kusimba. Inoshanda nekutevedzera maitiro eiyo diki-yakagadzirwa hormone GLP-1.

Synthesis process:

Exenatide acetate is a synthetic analog ye exendin-4, peptide hormone inogadzirwa neGila monster lizard. Inogadzirwa uchishandisa nzira inonzi solid-phase peptide synthesis (SPPS).

SPPS inzira yekugadzira peptides nekuwedzera nhanho yeamino acids kune inokura peptide cheni. Maitiro acho anoitwa pane yakasimba tsigiro, iyo inowanzova resin bead. Iyo amino acids inowedzerwa kune resin bead mune inoteedzana inoteedzana, uye yega yega amino acid inobatanidzwa kune inokura peptide cheni uchishandisa kemikari reaction.

Kana ketani yepeptide yapera, inotsemurwa kubva kubhedhi resin uye kucheneswa. Iyo peptide yakacheneswa inobva yaiswa acetylated kuita exenatide acetate.

  • Kuronga kweGum Globule: Nhanho yekutanga ndeyekumisa tar dot. Iyo pitch dot inogara yakagadzirwa ne polystyrene kana polyethylene glycol. Iyo gum dab inoshandiswa neine linker particle, iyo inobvumira maamino acids kuti abatanidzwe kune gum globule.

  • Kubatanidzwa kweMain Amino Corrosive: Iyo yekutanga amino corrosive inosanganiswa nepitch dot uchishandisa mhinduro yekugadzira. Iyo amino corrosive inogara yatangwa uchishandisa coupling reagent, semuenzaniso, dicyclohexylcarbodiimide (DCC) kana 1-hydroxybenzotriazole (HOBt).

  • Kubatanidzwa kweYakawanda Amino Acids: Maamino acids akawandisa anosanganiswa neketani irikuridzika yepeptide yega yega, zvichisanganisira mhinduro yechinhu chakafanana sechiri mu sync 2. Chikumbiro cheamino hachina kupedzwa neboka rakakodzera repeptide.

  • Cleavage yePeptide kubva kuTar Globule: Kana cheni yepeptide yapera, inochekwa kubva mumuto dab uchishandisa mhinduro yekomboni. Mhinduro yecleavage inogara ichipedzwa uchishandisa nzvimbo dzakakomba dzesimba, semuenzaniso, trifluoroacetic corrosive (TFA).

  • Kucheneswa kwePeptide: Iyo peptide yakatsemuka inocheneswa uchishandisa chromatography uye crystallization, pakati pedzimwe nzira.

  • Acetylation ye peptide: Iyo peptide yakacheneswa ndeye acetylated kune furemu exenatide acetic acid derivation. Mhinduro yeacetylation inowanzoitwa uchishandisa acidic anhydride kana acetyl chloride.

Maitiro Ehutano:

Exenatide acetate mushonga wepeptide unoshandiswa kurapa Type 2 chirwere cheshuga uye kufutisa. Iyo inogadzirwa analog ye exendin-4, hormone inogadzirwa neGila monster lizard. Exenatide acetate inogadzirwa uchishandisa maitiro anonzi solid-phase peptide synthesis.

Hunhu hwe exenatide acetate hwakakosha pakuchengetedza kwayo uye kushanda kwayo. Aya anotevera mamwe emhando yechigadzirwa zviyero zvinoshandiswa kune exenatide acetate:

  • Kuzivikanwa: Hunhu hweexenatide acetate hunosimbiswa uchishandisa nzira dzakasiyana siyana, senge superior execution fluid chromatography (HPLC) uye mass spectrometry.

  • Kuchena: Kusachena kwayo kuchiri mudenga nekufungidzira kuti kusvibiswa kwakawanda sei muchinhu chemushonga. Izvo zvinosvibisa zvinowanzoongororwa uchishandisa HPLC.

  • Potency: Iko kugona kusunga kune uye kumisa iyo GLP-1 receptor inoshandiswa kuona simba rayo. Simba racho rinowanzotaurwa mumayuniti eIU/mg.

  • Kubereka: Chinhu chemishonga isina utachiona.

Yihui, semugadziri anotungamira, anoomerera kune akaomesesa emhando zviyero kuti ave nechokwadi chekunaka kweExenatide Acetate. Maitiro edu ekugadzira anowirirana nemabhenji epasi rose, uye zvivakwa zvedu zvinozvirumbidza zvitupa zvinosanganisira ISO, Kosher, Halal. Izvi zvitupa zvinosimbisa kuzvipira kwedu kuendesa chigadzirwa chinosangana nepamusoro-soro indasitiri zviyero uye zvinotarisirwa zvinodiwa.

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Minda Yekushandisa muMaindasitiri Akasiyana:

Exenatide acetate ndeye GLP-1 receptor agonist iyo inoshandiswa kurapa rudzi rwechipiri chirwere cheshuga uye uremu. Iyo injinjini yakapusa ye exendin-2, kemikari inogadzirwa neGila chikara chinokambaira. Inowanzo shandiswa musanganiswa nemishonga yakasiyana, senge metformin kana sulfonylureas.

Zvisinei nekushandiswa kwayo mubhizimusi rezvinodhaka, yakaongororwawo kuti ishandiswe mumabhindauko akasiyana, anosanganisira:

  • Veterinarian tsika: Chirwere cheshuga muimbwa uye katsi chinogona kunyatsorapwa ne exenatide acetate. Inogara ichishandiswa mukusanganiswa nemishonga yakasiyana, se insulin.

  • Zvizoro: Ganda rakaratidzwa kuti rinobatsirwa kubva kune anti-aging migumisiro ye exenatide acetate. Inorangarirwa kushanda nekusimbisa kukura kwe collagen uye elastin, ayo mapuroteni maviri ane mhosva yekushanduka kweganda uye kusimba.

  • kuderedza mapaundi: Yakave yakaratidzwa kuva inomanikidzira mukusimudzira kuderedza uremu muvanhu vane uremu kana kuti vane huremu. Zvinorangarirwa kushanda nekudzivira havi uye kudzoreredza kubuda kwedumbu.

  • Kurapa kwezvimwe zvirwere zvemetabolic: Inogona kunge ine simba mukurapa zvimwe zvirwere zvemetabolism, senge isiri-doro greasy chiropa chirwere uye polycystic ovary kusagadzikana.

  • Neurodegenerative zvirwere zvinorapwa: Muzvidzidzo zvemhuka, iyo neuroprotective mhedzisiro ye exenatide acetate yakaratidzwa. Inorangarirwa kushanda nekuderedza aggravation uye oxidative pressure.

  • Kurapa kwechirwere: Yakaratidzwa kuve nekurwisa cancer kukanganisa muzvidzidzo zvezvisikwa. Inorangarirwa kushanda nekudzivisa kukura kwemasero ezvirwere uye kufambira mberi kwekuparara kwemasero ekukura akaipa.


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