Glecaprevir

CAS: 1365970-03-1
Chitarisiko: Muchena kune Off-White poda
Kuchengeta: 98%
Mucherechedzo: YIHUI
Kutakura: 1g; 10g; 100g
Kugovera Mano: 2000g pamwedziSherufu Hupenyu: Makore maviri
Chikumbiro: Lab research
Kubhadhara: T/T, LC kana DA
Muenzaniso: iripo
Nguva Yekutumira: Yakagadzirira Stock muNharaunda Warehouse, mazuva 1-3
Kurumidza uye Kuchengetedza Kutumira
Origin: China
Kutumira: DHL, FedEx, TNT, EMS,Negungwa,Nemhepo
Certifications: ISO9001, ISO22000, HACCP, HALAL, KOSHER
Haikwanisi kutengesera vanhu
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  • Quality Panga
  • 24/7 Vatengi Sevhisi
Product Introduction

Chii chinonzi Glecaprevir?

Glecaprevir mushonga unorwisa mavhairasi unoshandiswa kurapa chirwere chehepatitis C (HCV). Nekuda kwekuti iri protease inhibitor, inodzivirira HCV protease, enzyme inodiwa kuti hutachiona hudzokorore, kubva pakushanda. Glecaprevir inogara ichishandiswa mukusanganiswa nemamwe antiviral meds, semuenzaniso, sofosbuvir, kuita nhanho dzepamusoro dzekugadzirisa.

HCV chirwere chinotakura ropa chinogona kukonzera kukuvadza kwechiropa, cirrhosis, uye kukura kwechiropa. Hutachiona hunodzokororwa nekubata nharembozha yesero uye nekuishandisa kuendesa mamwe makopi matsva ehutachiona. Glecaprevir inoshanda nekuganhurira kuHCV protease uye kuichengeta kubva pakudimbura puroteni yakakosha yakakosha pakudzokorora kwehutachiona. Utachiona hahukwanisi kupeta uye kupararira nekuda kweizvi.

Inowanzo shandiswa musanganiswa nemamwe antiviral prescription kurapa kusvibiswa kweHCV. Iko kusanganiswa kweglecaprevir uye sofosbuvir, inotengeswa pasi pezita rechiratidzo Epclusa, ndiyo inonyanya kuzivikanwa. Epclusa ipiritsi kamwe-yezuva nezuva inotorwa kwenguva yakareba. Inogona zvakare kushandiswa musanganiswa nemamwe antiviral mishonga, senge pibrentasvir uye voxilaprevir. Aya masanganiswa anowanzo shandiswa kurapa vanhu vane hutachiona hweHCV hwakanyanya kana vanhu vakatadza kurapwa kwekare.

Glecaprevir-based regimens yakaratidzwa kuva inoshanda zvakanyanya mukurapa HCV. Mumakiriniki ekuedzwa, Epclusa yakawana yakasimbiswa virologic response (SVR) mazinga anopfuura 95% muvanhu vane chirwere chisingaperi cheHCV. SVR inotsanangurwa sekusava nehutachiona hunoonekwa muropa mavhiki gumi nemaviri mushure mekupedza kurapwa.

Glecaprevir kazhinji inobvumirwa zvakanaka. Migumisiro yakajairika ndeyekuneta, kutemwa nemusoro, uye kusvotwa. Izvi zvinokonzeresa zvakapfava uye zvinopera mukati memavhiki mashoma.


Basic Information

Zita reChigadzirwa: Glecaprevir

CAS: 1365970-03-1

MF:C38H46F4N6O9S

MW:838.87

MDL Nhamba:MFCD30533436

fomu Solid

ruvara White kusvika Off-White

Kuchena: 98%+

Package: 1g; 5g; 25g

Yakashandiswa: Tsvakurudzo yeLab

Kugadzikana: Kugadzikana

Structural fomula:

1365970-03-1.webp

Tsanangudzo Parameter:

chinhu  

Specification  

Results  

Kuonekwa  

Grey hupfu

Inopindirana  

Kuchena(HPLC)

≥98%

98.3%

mhedziso  

Zvinoenderana nezvinodiwa

Mushonga weKemikari:

GlecaprevirKuumbwa kwemakemikari kwakagadzirwa zvine hungwaru, kuve nechokwadi chekuita kwayo uye kuchengetedzeka. Zvikamu zvekutanga zvinosanganisira kabhoni (C), hydrogen (H), nitrogen (N), uye okisijeni (O). Kurongeka chaiko kwezvinhu izvi kunoita kuti Glecaprevir ishamise zvinhu uye kushanda kwemishonga.

Compound piece inonongedza kune yakakosha uye sub-atomic cosmetics yechinhu. Zvinoda kutaurirwa kusvika pazvikamu zvinoumba chinhu, zvimedu zviripo, kana mabikirwo ekugadzira zvinhu.

Kuumbwa kwechisikigo kwechinhu kunonongedza kuzvikamu zvinoumba chinhu uye zviyero zvakajairwa zvechikamu chose. Semuenzaniso, chikamu chekutanga chemvura ihydrogen neokisijeni, ine maota maviri ehydrogen pachikamu chimwe nechimwe cheokisijeni. Chinhu chakakosha chechinhu chinogona kugadziriswa uchishandisa nzira dzakasiyana dzine musoro, senge ongororo yechisikigo, spectroscopy, uye mass spectrometry.

Iyo sub-atomic kusikwa kwechinhu inonongedza kune zvidimbu zvinowanikwa muchinhu uye zviyero zvese zvechikamu chega chega. Mvura, semuenzaniso, ine mamorekuru ekuumbwa kweH2O, izvo zvinoratidza kuti molekuru yega yega ine atomu yeokisijeni uye maviri maatomu ehydrogen. Iyo sub-atomic kusikwa kwechinhu kunogona kugadziriswa pachishandiswa nzira dzakasiyana dzesainzi, senge chromatography, spectroscopy, uye mass spectrometry.

Mhedzisiro uye Mabasa:

Glecaprevir inozivikanwa nokuda kwemasimba ayo anodzivirira utachiona, kunyanya mukurwisa utachiona hwehepatitis C (HCV). Inodzivirira HCV NS3/4A protease, enzyme yakakosha pakudzokorora kwevhairasi, nekudaro kukanganisa kutenderera kwehupenyu hwehutachiona. Kubudirira kweGlecaprevir kunosvika kune yakafara spectrum yeHCV genotypes, zvichiita kuti ive inogoneka uye inovimbika mhinduro mundima yeantiviral therapy.

Utachiona hweHepatitis C (HCV) hunogona kurapwa nemishonga inorwisa mavhairasi inonzi glecaprevir. Iprotease inhibitor, zvinoreva kuti inodzivirira HCV protease enzyme kushanda. Izvi zvinokonzeresa zvakakosha pakudzokorora kwehutachiona hweHCV. Nekukanganisa kuita kwekemikari yeprotease, glecaprevir inochengetedza hutachiona kubva pakudzokorodza nekupararira.

Inowanzo shandiswa musanganiswa nemimwe mishonga inorwisa mavhairasi, semuenzaniso, sofosbuvir, kurapa chirwere cheHCV. Musanganiswa uyu mushonga unoshanda zvakanyanya pakudzoreredza chirwere cheHCV, nekugadzirisa mafambiro anodarika 95%. Mhedzisiro inonyanya kuzivikanwa yeglecaprevir inosanganisira kuneta, migraine, uye queasiness. Izvi zvechipiri zvinokonzeresa zvakapfava uye zvinonyangarika mushure mehafu yemwedzi yekurapwa.Kugona kweGlecaprevir kutadzisa kufamba kweHCV protease catalyst. Izvi zvinoita kuti utachiona hurege kudzoka uye kupararira, izvo zvinogona kukurumidza kugadzirisa kusvibiswa kweHCV.Iyo inhibitor ine simba uye yakananga yeHCV protease catalyst. Iyo inokwanisa kuvharidzira kuita kwe enzyme panguva yakaderera zvakanyanya uye ine yakanyanya kusunga hukama kune enzyme. Izvi zvinoita kuti uve mushonga unoshanda kwazvo wekurapa kusvibiswa kweHCV.

Glecaprevir mushonga wakachengetedzwa uye unomanikidza kurapa kusvibiswa kweHCV. Inogara ichishandiswa mukusanganiswa nemimwe mishonga inorwisa mavhairasi, semuenzaniso, sofosbuvir, kuita yakakwirira kugadzirisa mitengo. Glecaprevir inogona kudzora kuita kweHCV protease kemikari, iyo inochengetedza hutachiona kubva pakudzoka uye kupararira.

Synthesis process:

Iyo synthesis process ye Glecaprevir inobatanidza nhevedzano yenhanho dzakakwana uye dzakadzorwa kuti ive nechokwadi chekuchena uye kunaka kwechigadzirwa chekupedzisira. Kutanga nezvinhu zvakasarudzwa zvakasarudzwa, iyo synthesis inoenderera kuburikidza neakaomesesa kuita kwemakemikari, inotungamirwa neakaomesesa emhando yekudzora matanho.

  • Nhanho yekutanga ndeyekugadzira mhete yepyrrolidine, inova chikamu chakakosha cheglecaprevir. Izvi zvinoitwa nekuita ketone ine amine pamberi pemushonga unoderedza.

  • Nhanho inotevera ndeye alkylate mhete yepyrrolidine ine alkyl halide. Kuita uku kunowanzoitwa pamberi pebhesi.

  • Danho rechitatu kugadzira ringi imidazole, inova chimwe chikamu chakakosha cheglecaprevir. Izvi zvinoitwa nekuita iyo alkylated pyrrolidine mhete ine aldehyde pamberi peiyo acid catalyst.

  • Nhanho yechina ndeyekubatanidza imidazole nepyrrolidine zvindori pamwechete. Izvi zvinoitwa nekuita iyo imidazole mhete ine activated fomu yepyrrolidine ring.

  • Nhanho yechishanu ndeyekusuma boka retrifluoromethyl pane glecaprevir molecule. Izvi zvinoitwa nekuita glecaprevir ine trifluoromethylating agent.

  • Danho rekupedzisira nderekuchenesa glecaprevir kubvisa chero tsvina. Izvi zvinogona kusanganisira recrystallization kana chromatography.

Kugadzirwa kweglecaprevir inzira yakaoma uye yakaoma, asi yakakosha pakugadzirwa kweiyi yakakosha antiviral drug.

Iyo synthesis inotanga nekuunganidzwa kweakakosha epakati makomisheni, ayo anobva awedzera kunatswa kuti abudise yekupedzisira Glecaprevir chigadzirwa. Yihui's state-of-the-art zvivakwa uye makemikari ane ruzivo anovimbisa yakavimbika uye inodzokororwa synthesis maitiro, kusangana nepamusoro-soro indasitiri zviyero.

Quality Standards:

Yihui inosimudzira kuzvipira kune kugona mukugadzira Glecaprevir, kuomerera kune dzakaomesesa mhando zviyero. Maitiro ekugadzira anoitwa mukuteerana nemirairo yepasirese, uye chigadzirwa chakapedzwa chinoitwa kuomarara kwemhando yekuyedzwa. Yihui anodada akabata zvitupa zve ISO, Kosher, Halal, uye GMP (Zvakanaka Kugadzira Maitiro), zvichisimbisa kuzvipira kwedu kuendesa zvigadzirwa zvemishonga zvemhando yepamusoro.

Iwo emhando zviyero zveglecaprevir anosanganisira:

  • Kuzivikanwa: Mushonga wemushonga unofanirwa kunge uri glecaprevir uye kwete mumwe musanganiswa.

  • Kuchena: Mushonga wemushonga unofanirwa kunge usina tsvina, sekutanga zvinhu, zvepakati, uye zvinosvibisa zvigadzirwa.

  • Potency: Mushonga wemushonga unofanirwa kunge uine huwandu hwakakodzera hwechinhu chinoshanda.

  • Kuchengeteka: Mushonga unofanirwa kuve wakachengeteka kuti ushandiswe muvarwere. Izvi zvinosanganisira kuyedzwa kweiyo genotoxicity, carcinogenicity, uye huturu hwekubereka.

  • Efficacy: Mushonga wemushonga unofanirwa kunge uchishanda mukurapa chirwere chakatarwa kana mamiriro.

  • Chitarisiko: Mushonga wemushonga unofanirwa kuva chena kusvika kune-chena poda.

  • Solubility: Mushonga unofanirwa kunyungudika mumvura uye organic solvents.

  • Kugadzikana: Mushonga unofanirwa kugadzikana pasi pemamiriro akasiyana-siyana, kusanganisira tembiricha, hunyoro, uye chiedza.

Vagadziri veglecaprevir vanofanirwa kutevedzera Great Assembling Practices (GMP) kuti vavimbise kuti chinhu chemushonga chinozadzisa zvinotarisirwa zvemhando yese. GMPs iboka rezvirairo rinotarisira kuunganidzwa, kuyedzwa, uye kuparadzirwa kwezvinhu zvinodhaka

Minda Yekushandisa muMaindasitiri Akasiyana:

Glecaprevirs multifaceted applications inowedzera kupfuura nzvimbo yemishonga. Kukosha kwayo kunozivikanwa mumaindasitiri akasiyana siyana, kusanganisira hutano, masangano ekutsvagisa, uye makambani emishonga. Kuchinja-chinja kwekomboni kunoita kuti ive chishandiso chakakosha mukudzidza hutachiona hwehutachiona uye kugadzira mishonga yehunyanzvi.

  • Inoshandiswa sepakati mukugadzirwa kwemamwe mishonga yeHCV.

  • Inoshandiswawo mukugadzirwa kwemishonga mitsva yeHCV uye marapirwo.

  • Inoshandiswa muzvidzidzo zvekutsvagisa kuongorora maitiro eHCV kudzokorora uye kugadzira marapirwo matsva ehutachiona hweHCV.

  • Inogona zvakare kushandiswa mumaindasitiri anotevera:Mushonga wezvipfuyo: Glecaprevir inogona kushandiswa kurapa HCV chirwere mumhuka. 

  • Chikafu nechinwiwa indasitiri: Inogona kushandiswa kudzivirira HCV kusvibiswa kwechikafu nezvinwiwa.

  • Indasitiri yezvakatipoteredza: Inogona kushandiswa kurapa HCV-yakasvibiswa mvura uye ivhu.


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Taura nesu:

Yihui inobuda sechivheneko chekuvimba muindasitiri yemishonga, inogara ichiburitsa zvemhando yepamusoro. Glecaprevir izvo zvinoenderana nemitemo yenyika. Yedu ISO, Kosher, Halal, uye GMP zvitupa zvinosimbisa kuzvipira kwedu kune kugona. Nekubvunza uye kutenga, ndapota taura nesu pa sales@yihuipharm.com. 

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