GSK126

CAS: 1346574-57-9
Kuonekwa: Off-White powder
Kuchengeta: 98%
Mucherechedzo: YIHUI
Kutakura: 1g; 10g; 100g
Kugovera Mano: 2000g pamwedzi
Sherufu Hupenyu: Makore maviri
Chikumbiro: Lab research
Kubhadhara: T/T, LC kana DA
Muenzaniso: iripo
Nguva Yekutumira: Yakagadzirira Stock muNharaunda Warehouse, mazuva 1-3
Kurumidza uye Kuchengetedza Kutumira
Origin: China
Kutumira: DHL, FedEx, TNT, EMS,Negungwa,Nemhepo
Certifications: ISO9001, ISO22000, HACCP, HALAL, KOSHER
Haikwanisi kutengesera vanhu
  • Fast Delivery
  • Quality Panga
  • 24/7 Vatengi Sevhisi
Product Introduction

Chii chinonzi Gsk126?

Gsk126 inhibitor chaiyo yeglycogen synthase kinase-3 (GSK-3) iyo yakaratidza kuvimbisa kunobatsira mumhando dzakasiyana dzechirwere. GSK-3 inonzi serine / threonine kinase inotora chikamu chekutanga mumutungamiri weglycogen digestion, kukura kwesero uye kuparadzaniswa, uye apoptosis. Dysregulation yeGSK-3 chiito chave chakabatwa mune pathogenesis yezvirwere zvishomanana, kusanganisira rudzi rwechipiri chirwere cheshuga, chirwere cheAlzheimer, uye chirwere.

Inodzivirira kutamiswa kwephosphate kubva kuATP kuenda kune serine kana threonine zvisaririra pamapuroteni anonangwa nekusunga muhomwe yeATP-inosunga enzyme. Ichi chipingamupinyi chinounza kutangwa kwenzira dzekudzika mureza dzinosimudzira kutsungirira kwesero, kusimudzira, uye kupatsanurwa.

Mukuongororwa kwe preclinical, Gsk126 yakaratidza kushanda mumhando dzakasiyana dzechirwere. Semuyenzaniso, mumhando dzezvisikwa zverudzi rwechipiri rwechirwere cheshuga, zvakawedzera kuita insulini kuita uye kusimba kweglucose. Mune mhando dzechirwere cheAlzheimer icho chakadzikira amyloid-beta plaque kuronga uye yakashanda pakugona kwepfungwa. Mune mhando dzechirwere, yakadzora kukura kwegomarara uye metastasis.

Zvakaita sezviri kuongororwa mumakiriniki ekutanga kurapwa kwehurwere hushoma, kusanganisira Type 2 chirwere cheshuga, chirwere cheAlzheimer, uye kukura kwakashata. Zvichifambira mberi basa 2 preliminaries mune varwere vane rudzi rwechipiri chirwere cheshuga vakaratidza izvozvo Gsk126 inodzivirirwa uye kumativi ose akatsungirirwa uye kuti inogona kuwedzera kukudziridza kuziva kwe insulin uye kutonga kweglucose. Zvishoma nezvishoma shandai 2 preliminaries muvarwere vane chirwere cheAlzheimer zvakaratidzawo kuti inodzivirirwa uye inotsungirira zvakanyanya uye kuti inogona kushanda pakugona kwepfungwa. Shanda 3 preliminaries muvarwere vane Type 2 chirwere cheshuga uye chirwere cheAlzheimer chiri kuenderera mberi.


Basic Information

Zita reChigadzirwa: GSK126

CAS: 1346574-57-9

MF:C31H38N6O2

MW:526.67

fomu Solid

ruvara Off-White

Kuchena: 98%+

Package: 1g; 5g; 25g

Yakashandiswa: Tsvakurudzo yeLab

Kugadzikana: Kugadzikana

Structural fomula:

1346574-57-9.webp

Zvinotsanangurwa uye Parameters:

Ngationgororei mune tekinoroji maficha eGsk126 kuburikidza neyakadzama yakatarwa uye paramita tafura:

chinhu  

Specification  

Results  

Kuonekwa  

Grey hupfu

Inopindirana  

Kuchena(HPLC)

≥98%

98.3%

mhedziso  

Zvinoenderana nezvinodiwa

Mushonga weKemikari:

Gsk126's Chemical composition inonyatso kuenderana musanganiswa wakagadzirirwa kuve nechokwadi chekushanda kwakakwana. Heino rondedzero:

chikamuPercentage Composition
GSK12699%

Basa uye Basa:

Gsk126 inhibitor chaiyo yeglycogen synthase kinase-3 (GSK-3) iyo yakaratidza kuvimbisa kunobatsira mumhando dzakasiyana dzechirwere. GSK-3 inonzi serine / threonine kinase inotora chikamu chekutanga mumutungamiri weglycogen digestion, kukura kwesero uye kuparadzaniswa, uye apoptosis. Dysregulation yeGSK-3 chiito chave chakabatwa mune pathogenesis yezvirwere zvishomanana, kusanganisira rudzi rwechipiri chirwere cheshuga, chirwere cheAlzheimer, uye chirwere.

Icho chinhu chakakosha chekudzora glycogen digestion. Iyo phosphorylates uye inactivates glycogen synthase, puroteni inopindurwa yemubatanidzwa weglycogen. Uku kudziviswa kweglycogen synthase kunounza kuparara kweglycogen uye kusvika kweglucose muhurongwa hwekutenderera. Gsk126 inodzivisa GSK-3, maererano nekudzivirira phosphorylation uye kusashanda kweglycogen synthase. Izvi zvinoguma mukuwedzera glycogen musanganiswa uye kuderera kweglucose kubuda muhurongwa hwekutenderera.

Iyo zvakare inotora chikamu mugwara rekukura kwesero uye kupatsanurwa. Iyo phosphorylates uye inotanga cyclin D1, puroteni yakakosha pakufamba kwesero. Gsk126 inodzvinyirira GSK-3, zvichienderana nekudzivirira phosphorylation uye kutangwa kwecyclin D1. Izvi zvinoguma mukudzivirira kwekufamba kwesero cycle uye kufambira mberi kwekuparadzaniswa kwesero.

Dysregulation yeGSK-3 chiito chave chakabatanidzwa mune pathogenesis yezvirwere zvishomanana, kusanganisira chirwere cheshuga chechipiri, chirwere cheAlzheimer, uye chirwere. Murudzi rwechipiri chirwere cheshuga, GSK-2 inonyanya kushanda, izvo zvinokurudzira kuwedzera kuparara kweglycogen uye kubuda kweglucose muropa rekutenderera. Izvi zvinogona kukonzera insulin kushorwa uye hyperglycemia. Muchirwere cheAlzheimer, Inowedzera kushanda zvakanyanya, izvo zvinokurudzira kugadzirwa kweamyloid-beta plaques uye neurofibrillary tangles, zviviri zvezviratidzo zvehurwere. GSK-2 inowanzoshanda zvakanyanya mukenza, iyo inogona kukonzera kuwedzera kwesero kukura uye kupararira uye kushoma apoptosis.

Synthesis process:

Gsk126 inhengo yekugadzira isingawanikwe yakasikwa. Inogadzirwa mune yakawanda-nhanho nhanho iyo inowanzotanga nekuita kwe4-chloro-3-fluorobenzaldehyde ne 2-bromo-4'-methoxyacetophenone kuti iite musanganiswa wepakati. Iyi yepakati inobva yaitwa ne 3-aminopyridine kuti iite imwe yepakati pakati. Izvi zvepakati zvinobva zvaitwa ne 4-fluorobenzoyl chloride kugadzira chigadzirwa chekupedzisira, Gsk126.

The synthesis ye Gsk126 inzira yakaoma inoda hunyanzvi hwekushandisa uye hunyanzvi. Inowanzoitwa nemakambani emishonga kana masangano ekutsvagira makondirakiti.

  • Step 1: Reaction ye 4-chloro-3-fluorobenzaldehyde ine 2-bromo-4'-methoxyacetophenone kuumba musanganiswa wepakati.

  • Step 2: Kuita kwemusanganiswa wepakati kubva paChikamu chekutanga ne 1-aminopyridine kuumba imwe yepakati pakati.

  • Step 3: Kuita kwemushonga wepakati kubva paChikamu chechipiri ne 2-fluorobenzoyl chloride kuumba chigadzirwa chekupedzisira, Gsk4.

Kamwe iyo synthesis ye Gsk126 yapera, chigadzirwa chinofanira kunatswa kubvisa chero tsvina. Izvi zvinowanzoitwa pachishandiswa nzira dzakasiyana siyana, senge recrystallization, chromatography, uye kusefa. Chigadzirwa chakacheneswa chinozoiswa pasi pekuomesera kudzora kwemhando kuyedzwa kuti ive nechokwadi chekuti inosangana nezvinodiwa zvekuchengetedza uye kushanda.

Iyo synthesis yacho inzira yakaoma inoda hunyanzvi hwekushandisa uye hunyanzvi. Inowanzoitwa nemakambani emishonga kana masangano ekutsvagira makondirakiti. Matanho anokosha mukugadzirisa maitiro anosanganisira maitiro e4-chloro-3-fluorobenzaldehyde ne 2-bromo-4'-methoxyacetophenone, inoteverwa nekuita kwekamuti yepakati ne 3-aminopyridine uyezve 4-fluorobenzoyl chloride. Kana iyo synthesis yapera, chigadzirwa chinofanira kucheneswa uye kuiswa pasi pekuongororwa kwemhando yepamusoro isati yashandiswa kumiedzo yekiriniki kana kugadzirwa kwekutengesa.

Product Quality Standards :

Hunhu haugone kutaurirana paYihui, uye hazvisi izvo. Yakagadzirwa zvakanyatsoenderana nemitemo yenyika, maitiro edu ekugadzira anotevedzera ISO, Kosher, Halal, uye GMP certification. Matanho akasimba ekudzora emhando anoitwa padanho rega rega, kuve nechokwadi chekuti batch yega yega Gsk126 inosangana nezviyero zvepamusoro-soro zvekuchena, kushanda, uye kuchengeteka.

  • Kuzivikanwa: Chinhu chacho chinofanirwa kunyatso zivikanwa uye chinoenderana nezvisungo zveGsk126.

  • Kuchena: Chinhu chacho chinofanira kusunungurwa kubva pakusvibiswa, semuenzaniso, zvakasiyana-siyana zvekugadzira makomisheni kana zvinonyungudutsa zvinogona kunge zvakashandiswa mukuunganidza system.

  • Potency: Chinhu chacho chinofanirwa kunge chine chiyero chakakodzera cheGsk126 uye chinosangana nemazita emagetsi anonzi.

  • Kudzivirirwa: Chigadzirwa chacho hachifanirwe kunge chine chero chinosvibisa uye chinofanira kunge chakachengeteka kuti chishandiswe nevanhu.

  • Efficacy: Chinhu chacho chinofanira kuva chakasimba mukurapa chirwere chakarongwa kana mamiriro.

Minda Yekushandisa muMaindasitiri Akasiyana:

Gsk126 inowana zvikumbiro mumaindasitiri akasiyana siyana, ichiratidza mashandiro ayo. Muchikamu chemishonga, inoshanda sechinhu chakakosha mukuvandudza zvinodhaka, kunyanya mumunda wekutsvagisa cancer. Yayo epigenetic modulation masimba anovhura mikova kune itsva nzira dzekurapa.

  • Diabetes: Iri kutariswa senzira yekurapa chirwere cheshuga cherudzi rwechipiri. Zvinorangarirwa kushanda nekuenderera mberi nekuvandudza insulin inopindura uye kutonga kweglucose.

  • Chirwere cheAlzheimer: Iri zvakare kuiswa semushonga unobvira wechirwere cheAlzheimer. Inorangarirwa kushanda nekudzivisa kukura kweamyloid plaques, iyo chiratidzo chetachiona.

  • Cancer: Iri kutariswa senzira yekurapa yeleukemia, lymphoma, uye colon cancer, pakati pemamwe marudzi egomarara. Inorangarirwa kushanda nekudzivisa kukura kwesero uye kuwanda.

  • Anti-agnha: Iyo yakaratidzwa kutadzisa kuvandudzwa kwe melanin, iyo inokonzera ganda pigmentation. Izvi zvinokurudzira kuti inogona kunge yakatarisira mashandisirwo mumuvengi wekukura zvigadzirwa zvekuchengeta runako.

  • Kureruka kweganda: Inogonawo kubatsira mune zvigadzirwa zvinorerutsa ganda. Nekutadzisa kugadzirwa kwe melanin, inogona kubatsira nekudzikisira kuvepo kwemavara madiki uye hyperpigmentation.

  • Inishuwarenzi yezvirimwa: Yakaratidzwa kutadzisa kuvandudzwa kwekukura uye tupukanana tunogona kukuvadza zvirimwa. Izvi zvinokurudzira kuti inogona kunge iine maapplication mukuchengetedza chirimwa.

  • Biotechnology: Icho chishandiso chinobatsira chekuongorora basa iro GSK-3 inotamba mune dzakasiyana siyana biological process. Inoshandiswa kudzidza kusaina kwesero, metabolism, uye chirwere mumarabhoritari pasi rese.

  • Kuvandudzwa kwezvinodhaka: Inoshandiswazve mukuzivisa zvinodhaka kuedza kuona zvirinani kupfuura kare mishonga yezvirwere zvakasiyana.

Mumunda we regenerative medicine, Gsk126Kugona kwekuita mukupesvedzera mutsauko we stem cell kwatora kutariswa. Izvi zvinozvimisa semutambi akakosha mukutsvaga mishonga mitsva yezvirwere zvinopera simba.

 

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