Abaloparatide upfu

CAS: 247062-33-5
Kuonekwa: White powder
Standard: mumba
Kugovera Mano: 100kg pamwedzi
Sherufu Hupenyu: Makore maviri
Kushandisa: Pharmaceutical Peptide
Kubhadhara: T/T, LC kana DA
Nguva Yekutumira: Yakagadzirira Stock muNharaunda Warehouse, 1-3 mazuva
Kurumidza uye Kuchengetedza Kutumira
Origin: China
Kutumira: DHL, FedEx, TNT, EMS, NeGungwa, Nemhepo
Certifications: ISO9001, ISO22000, HACCP, HALAL, KOSHER
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Product Introduction

Chii chinonzi Abaloparatide poda

Abaloparatide upfu i peptide inoumbwa ne34 amino acid yasara. Ihomoni itsva yeparathyroid ine chekuita nepeptide(PTHrP) yakagadzirwa neRadiosHealth. Chinhu chakakosha picky activator yePTH- I receptor, iyo inogona kuwedzera bone mineral content, bone viscosity, uye simba rebhonzo, kukurudzira kuwirirana kwebhonzo, uye yakagamuchirwa neFDA musi waApril 28, 2017. Zita rayo rekutengeserana ndiTymos. Subcutaneous jekiseni reabapatide rinoshandiswa kurapa osteoporosis muvakadzi vane postmenopausal panjodzi yekutyoka kana kusashanda nemimwe mishonga yekurapa, iyo inogona kunyatso kudzikisa kuwanda kweiyo vertebral uye isina vertebral fractures. Kuenzaniswa ne tripeptide, inogona kuderedza kuwanda kwekutsemuka uye hypercalcemia.

Iyo inosarudzika activator yeparathyroid hormone receptor (PTH1 receptor), uye nekuda kwekuita kwayo kwakanakisa osteogenic, mishonga inogadzirwa kubva kuabapatide yakasimudzirwa kukiriniki yekuvandudzwa kwekurapa postmenopausal osteoporosis muvakadzi vane njodzi yakanyanya yekutyoka.

 

Basic Information

Zita reChigadzirwa: Abaloparatide

CAS: 247062-33-5

MF:C174H300N56O49

MW:3960.5896

Zvinoteverana:Ala-Val-Ser-Glu-His-Gln-Leu-Leu-His-Asp-Ls-Gly-Lys-Ser-Ile-Gln-Asp-Leu-Arg-Arg-Arg-Glu-Leu-Leu-Glu- Lys-Leu-Leu-Aib-Lys-Leu-His-Thr-Ala-NH2

Kuchena: 99%+

Package: 1g; 5g; 100g

MOQ: 1g

Origin: China

Package: 1g; 5g; 10g

Yakashandiswa: API

Kugadzikana: Kugadzikana

Nguva yekuendesa: 3-7mazuva

Structural fomula:

chigadzirwa-1-1

 

Technical Specification:

chinhu

Specification

Kuonekwa

Muchena kusvika pachena-poda yakachena

Kuchena(HPLC)

≥98.0%

Kusachena Kumwechete

≤2.0%

Acetate Content (HPLC)

5.0% ~ 12.0%

Zvemumvura (Karl Fischer)

≤10.0%

Peptide Content:

≥80.0%

Kurongedza uye Kutumira: Kudziya kwakadzika, vacuum kurongedza, kwakaringana kumg sezvinodiwa.

 

basa:

(1) Kukurudzira kugadzirwa kwe insulin

Abaloparatide powder inogona kukurudzira pancreatic islet masero kuti abudise insulin, nokudaro kuderedza mazinga ehuga. Pamusoro pezvo, inogona zvakare kuwedzera kunzwa kwe insulin, Iite kuti ishande.

(2) Kudzivisa gastric acid stashing
inogona kutadzisa kuvharika kwegastric acid, nokudaro kuderedza kukurudzirwa kwegastric mucosa negastric acid uye kuderedza kusagadzikana mudumbu.
3) Kugadzirisa kusanganiswa kwe insulin-yakadai sekukura chinhu
inogona kukurudzira kusanganiswa kwe insulin-yakadai sekukura kwechinhu, nokudaro ichikurudzira kuwanda kwesero uye kuparadzaniswa, uye kutamba chimwe chikamu muchimiro chesero uye kusimbazve.

 

Application:

Kushandiswa kweAbapaptide kunonyanya kuratidzwa mune zvinotevera zvinhu:

(1) Kuderedza mwero weshuga

Inogona kukurudzira insulin secretion uye kuderera kweshuga yeropa, iyo inonyanya kukosha kune vane chirwere cheshuga.

(2) Kuderedza kusagadzikana mudumbu

Inogona kurambidza gastric acid secretion uye kuderedza kusagadzikana kwemudumbu, ichipa kumwe kuzorora kwezviratidzo zvakaita sekurwadziwa kwemudumbu uye kusadya.

(3) Kukurudzira kugadzirisa uye kuvandudzwa kwesero

Inogona kusimudzira kuumbwa kwe insulin-sekukura chinhu, zvichitungamira mukuwanda kwesero uye kusiyanisa, uye kuita imwe mhedzisiro pakugadzirisa masero uye kuvandudzwa, ichipa rubatsiro mukurapa maronda uye kugadzirisa kwematishu.

Muchidimbu, Iyo yakakosha kwazvo biomolecule ine akawanda biological mabasa uye pharmacological mhedzisiro, ichiita basa rakakosha muhutano hwevanhu.

 

Kugadzirira nzira

Abapa peptide i polypeptide inoumbwa ne 34 amino acid zvisaririra. Iyo patented nzira yeAbapa peptide inoburitswa. Chekutanga, iyo yakasimba -phase synthesis nzira inoshandiswa kugadzira 3 peptide resin zvidimbu. CHICALBOOK Chikamu chekutanga chakabatana. Zvisinei, kuomeswa kwechando kunodiwa kusati kwabatanidzwa peptide zvidimbu 1 ne2, uye kugadzirwa kwepeptide resin zvidimbu 3 ne2 zvinoda mari yakawanda inodhura 3-CTC resin, zvichiita kuti mari yekugadzira iwedzere.

 

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