Bivalirudin Trifluoroacetate

CAS: 128270-60-0
Kuonekwa: kuchena kusvika kune-white powder
Standard: usp
Kushandisa: Anticoagulant & lab tsvakurudzo
Mucherechedzo: YIHUI
Kutakura: 1g; 10g; 100g
Kugovera Mano: 20kg pamwedzi
Sherufu Hupenyu: Makore maviri
Kubhadhara: T/T, LC kana DA
Muenzaniso: iripo
Nguva Yekutumira: Yakagadzirira Stock muNharaunda Warehouse, mazuva 1-3
Kurumidza uye Kuchengetedza Kutumira
Origin: China
Kutumira: DHL, FedEx, TNT, EMS,Negungwa,Nemhepo
Certifications: ISO9001, ISO22000, HACCP, HALAL, KOSHER
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Product Introduction

Chii chinonzi Bivalirudin Trifluoroacetate?

Bivalirudin trifluoroacetate inhibitor inogadzirwa, yakananga thrombin inhibitor inoshandiswa mukurwisa uye kurapwa kweapoplexy. Iyo ine simba uye yakananga inhibitor ye thrombin, iyo yakakosha inokonzeresa mu coagulation mafashama. Bivalirudin trifluoroacetate inotungamirwa nemutsinga uye ine kukurumidza kwekutanga kwekuita. Inoshandiswa neitsvo uye ine hafu-inowanikwa maminitsi makumi maviri nemashanu.

Inosungirirana kune inosimba saiti yethrombin, ichiichengeta kubva pakuchinja fibrinogen pamusoro zvachose kusvika fibrin. Izvi zvinotadzisa kugadzirwa kweropa. Uyezve, kushandiswa kweplatelet, iyo inokonzera kukura kwekuvhara ropa, inodziviswa ne bivalirudin trifluoroacetate.


Basic Information

Product Name: Bivalirudin Trifluoroacetate

CAS: 128270-60-0

MF:C98H138N24O33

MW:2180.29

EINECS: 274-570-6

MDL Nhamba:MFCD08282793

Kuchena: 98%+

Package: 1g, 10g, 25g, 500g

Inoshandiswa: tsvagiridzo uye pharma giredhi

Kugadzikana: Kugadzikana

Structural fomula:

128270-60-0.webp

Sequence: D-Phe-Pro-Arg-Pro-Gly-Gly-Gly-Gly-Asn-Gly-Asp-Phe-Glu-Glu-Ile-Pro-Glu-Glu-Tyr-Leu-OH

Chengetedza pa: Nzvimbo yakaoma yakaoma (2-8oC, kure nechiedza)

Zvinotsanangurwa uye Parameters:

Ngatitangei nekuongorora zvakatemwa uye paramita yeBivalirudin Trifluoroacetate. Ruzivo urwu rwakakosha kune nyanzvi mumunda kuti ive nechokwadi chekushandisa kwakaringana uye kunoshanda. Ndokumbira utarise tafura iri pazasi kuti uwane zvakadzama zvirevo:

miedzo

Magadzirirwo

Results

Kuonekwa

White powder

Inoenderana

Kuchena(HPLC)

≥99%

99.4%

Kusachena Kumwechete (HPLC)

≤1.0%

Inoenderana

Trifluoroacetate Content (HPLC)

5.0% ~ 10.5%

7.8%

Peptide Content (N%)

≥80.0%

89.4%

Zvemumvura (Karl Fischer)

≤10.0%

4.11%

Bacterial endotoxin

≤5EU/mg

Inoenderana

MS (ESI)

Inoenderana

Inoenderana

Mass Balance

95.0 ~ 105.0%

Inoenderana

mhedziso:

Inoenderana neyakajairwa nemugadziri

Kemikari Kuumbwa:

Kunzwisisa kuumbwa kwemakemikari kwakakosha kune nyanzvi mune zvemishonga uye zvekurapa zvikamu. Tarisa kune tafura iri pasi apa kuti uwane kupatsanurwa kwezvinhu zvakakosha:

chikamuPercentage Composition
Bivalirudin95%
Trifluoroacetate5%

Basa uye Basa:

Bivalirudin trifluoroacetate is immediate thrombin inhibitor iyo inoshandiswa mukurwisa uye kurapwa kweapoplexy. Iyo ine simba uye yakananga inhibitor ye thrombin, iyo yakakosha inokonzeresa mu coagulation mafashama. Bivalirudin trifluoroacetate inosungirirana kune inoshanduka saiti yethrombin, ichiichengeta kubva pakuchinja fibrinogen pamusoro zvachose kusvika fibrin. Izvi zvinotadzisa kugadzirwa kweropa. Uyezve, kushandiswa kweplatelet, iyo inokonzera kukura kwekuvhara ropa, inodziviswa ne bivalirudin trifluoroacetate.

Inoshandiswa munzvimbo dzakasiyana dzekiriniki, kusanganisira:

  • Percutaneous coronary mediation (PCI): Inoshandiswa kudzivirira apoplexy panguva yePCI, nzira iyo stent inogadzikwa mutsinga shoma kuti ienderere mberi nekuvandudza kuyerera kweropa.

  • Yakanyanya coronary mamiriro (ACS):Inoshandiswa kurapa ACS, mamiriro ezvinhu umo kune kusingatarisirwi kuderera muropa rekuyerera kumwoyo.

  • Kushungurudzika kwemoyo (AF): Mune varwere vane AF, mamiriro ezvinhu umo mwoyo unorova zvisingaite, mushonga wekudzivirira thrombosis bivalirudin trifluoroacetate inoshandiswa.

  • Profound vein apoplexy (DVT): Inoshandiswa kurapa DVT, mamiriro ezvinhu umo ropa coagulation rinogadzira mutsinga yakadzika, kazhinji mugumbo.

  • Aspiratory embolism (PE): PE mamiriro ekuti ropa rinoputika rinofamba kubva mutsinga yakadzika kusvika kumapapu uye rinorapwa ne bivalirudin trifluoroacetate.

Synthesis process:

Iyo synthesis process inosanganisira akati wandei akaomesesa matanho ekuona iyo yepamusoro mhando ye Bivalirudin Trifluoroacetate. Izvo zvikamu zvekutanga zvinopinda maitiro akadzorwa, zvichitungamira pakuumbwa kwechigadzirwa chekupedzisira. Maitiro aya anosanganisira akaomesesa ekudzora nhanho kuti asangane nedzimwe nyika.

  • Solid-phase peptide synthesis: Chikamu chepeptide chayo chinogadzirwa uchishandisa solid-phase peptide synthesis (SPPS). SPPS inzira yekugadzira peptides umo peptide inounganidzwa pane yakasimba rutsigiro, imwe amino acid panguva. Iyo amino acids inowedzerwa kune yakasimba tsigiro mune inoteedzana inodiwa, uye yega yega amino acid inobatanidzwa kune inokura peptide cheni uchishandisa coupling reagent. Kana ketani yepeptide yapera, inotsemurwa kubva patsigiro yakasimba uye inocheneswa.

  • Trifluoroacetylation: Iyo peptide inobva yaita trifluoroacetylated kuita bivalirudin trifluoroacetate. Trifluoroacetylation idenderedzwa umo trifluoroacetyl boka rinowedzerwa kuN-kumagumo kwepeptide. Izvi zvinowanzoitwa uchishandisa trifluoroacetic anhydride mukati mekuona kwebhesi.

  • Kunatswa: Chigadzirwa chacho chinobva chasvibiswa nekushandisa nzira dzakasiyana-siyana, senge chromatography uye crystallization. Izvi zvinopedzwa kubvisa chero debasements kubva mushonga chinhu.

  • Kugadzirisa: Iyo sanitized chigadzirwa chinozorongwa kuita inonzwisisika kuyerwa chimiro, semhinduro yekupinza. Izvi zvinogona kusanganisira kuwedzera zvigadziriso zvakasiyana, senge cradles, additives, uye stabilizers.

  • Saizi yakakura yepeptide: Iyo peptide yakakura zvine mwero, inosanganisira makumi maviri amino acids. Izvi zvinoita kuti zvive zvakanyanya kunetsa kubatanidza pane mamwe ane mwero peptides.

  • Kuvapo kweakasiyana chiral anotarisa: Iine akawanda chiral inotarisa. Izvi zvinotarisira kuti kune akawanda anofungidzirwa stereoisomers emushonga. Izvo zvakakosha kubatanidza iyo stereoisomer chaiyo, sezvo mamwe mastereoisomers anogona kuita akasiyana kana kutokuvadza maitiro.

  • Chinodiwa chekunaka kwepamusoro: Inofanira kunge iri yemhando yepamusoro-soro kuti ichengetedzwe uye inomanikidza. Izvi zvinodaro nechikonzero chekuti kunyangwe huwandu hushoma hwekusvibisa hunogona kukanganisa hutano hwemushonga uye kukwana.

Hunhu hweChigadzirwa:

Bivalirudin trifluoroacetate chinhu chinodhaka, uye zvinhu zvese zvinotariswa, zvinofanirwa kuzadzisa nhungamiro yemhando yekuchengetedzwa uye kubudirira kushandiswa muvarwere. Aya misimboti yemhando yakamiswa nenyanzvi dzekutonga, seUS Food and Medication Organisation (FDA) neEuropean Meds Office (EMA).

Iyo yemhando yemisimboti ye bivalirudin trifluoroacetate dzinosanganisira:

  • Kuzivikanwa: Mushonga unofanira kunge uri zvauri kunzi uri. Izvi zvinogara zvichiyedzwa pachishandiswa nzira dzakasiyana-siyana dzine musoro, senge chromatography uye spectroscopy.

  • Kuchena: Mushonga unofanirwa kusunungurwa kubva kune zvakaderedzwa, senge zvakasiyana zvekugadzira zvinhu, zvinonyungudutsa, uye tupukanana. Izvi zvinogara zvichiyedzwa pachishandiswa nzira dzakasiyana dzesainzi, senge chromatography uye spectroscopy.

  • Potency: Mushonga unofanirwa kuva nesimba rakajairika kana chiito. Izvi zvinowanzoyedzwa uchishandisa akasiyana masikirwo ekuongorora.

  • Kudzivirirwa: Varwere vanofanira kukwanisa kunwa mushonga zvisina njodzi. Izvi zvinowanzoyedzwa uchishandisa zvisikwa zvakasiyana uye bvunzo dzevanhu.

Pamusoro pezviyero zvemhando yepamusoro, bivalirudin trifluoroacetate inofanirawo kusangana nemhando yakatarwa yemhando yekushandiswa kwayo.

Yihui inochengetedza zvimiro zvemhando yepamusoro zveBivalirudin Trifluoroacetate kugadzirwa. Maitiro anoomerera kune ISO, Kosher, Halal, uye GMP certification, kuve nechokwadi chekuti chigadzirwa chinosangana nepamusoro-soro mabhenji epasirese. Izvi zvitupa zvinosimbisa kuzvipira kwaYihui kuendesa mishonga yemhando yepamusoro.

Minda Yekushandisa muMaindasitiri Akasiyana:

Bivalirudin Trifluoroacetate inowana maapplication mumaindasitiri akasiyana, kunyanya mukati mechikamu chekurapa nemishonga. Kushandiswa kwayo muanticoagulation kurapa kunoita kuti ive yakakosha muzvipatara, makiriniki, uye mamwe masangano ehutano. Kuchinja-chinja kwechigadzirwa kunosvika kumarabhoritari ekutsvagisa, zvichibatsira mukufambira mberi mukurapa kwemoyo.

  • Cardiology:Inoshandiswa kudzivirira uye kurapa masumbu eropa muvarwere vanoenda kuburikidza nepercutaneous coronary mediation (PCI), senge stent kuronga. Inoshandiswawo kurapa yakanyanya coronary disorder (ACS), mamiriro ezvinhu anosanganisira kutadza kwemoyo uye angina isina kugadzikana.

  • Neurology: Inoshandiswa kudzivirira kuputika kweropa muvarwere vanoenda kuburikidza necarotid endarterectomy, nzira yekurapa yekubvisa plaque kubva mu carotid course.

  • Muscular medical procedure: Inoshandiswa kudzivirira majuru eropa muvarwere vanoenda kuburikidza nemhasuru yekurapa, sekutsiva hudyu nemabvi.

  • Vascular medical procedure: Inoshandiswa kudzivirira masumbu eropa muvarwere vanoenda kuburikidza nevascular nzira yekurapa, semuenzaniso, kufuratira maitiro ekurapa uye aneurysm kugadzirisa.

  • Zvimwe: Inoshandiswawo kudzivirira nekurapa masumbu eropa muvarwere vane atrial fibrillation (AF), profound vein apoplexy (DVT), uye pneumonic embolism (PE).


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