Melanotan-II powder

Nhamba yeCAS: 121062-08-6
Chitarisiko: Muchena kana chena fluffy poda
Standard: Enterprise Standard
Kugovera Mano: 50kg pamwedzi
Sherufu Hupenyu: Makore maviri
Kubhadhara: T/T, LC kana DA
Nguva Yekutumira: Yakagadzirira Stock muNharaunda Warehouse, 1-3 mazuva
Origin: China
Kutumira: DHL, FedEx, TNT, EMS, NeGungwa, Nemhepo
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Product Introduction

Isu tinopa Melanotan-II

Tinodada kupa Melanotan-II powder, peptide inogona kukurudzira melanin chigadzirwa uye inokanganisa mune yakanaka, yebronze tan. Kunyangwe iwe uri kutsvaga kugadzirira chiitiko chakakosha kana kungoda kusimudzira yako yakasikwa ganda toni, MTII mhedzisiro yakachengeteka uye inoshanda. Chigadzirwa chedu chakanyatso gadzirwa kuti chichengetedze hutsva uye kuchena, uye takazvipira kupa ruzivo rwepamusoro mutengi. Neyedu yemhando yepamusoro Melanotan 2, unogona kuwana ganda rebronze, rine hutano-raunogara uchizvikudza. Ronga nguva yako uye uzvionere mabhenefiti eMelanotan II.

 

Chii chinonzi Melanotan-II?

Melanotan-II inoshanda zvakanyanya pakutsvuka ganda rakagadzirirwa kusviba ganda pasina chikonzero chekusangana nezuva. Iyi greasepaint ine dudziro yekugadzira yehomoni melanocortin inosunga kumaseru anogadzira melanin muganda, anozivikanwawo semelanocytes, kuwedzera chigadzirwa chemelanin uye kusviba ganda.

Inoshandiswa nevanhu vanoda kuwana ganda rakarohwa chitarisiko pasina kutyisidzira kwekukuvadzwa kweganda kunokonzerwa nekushayikwa kwezuva. Zviri nyore kushandisa, uye zvese zvaunofanirwa kuita kuzvisanganisa nemhedzisiro yacho uye woiisa muganda rako kuti inokurumidza uye inoshanda mhedzisiro.

Ichi chigadzirwa chakakurumbira pakati pevanovaka muviri, vanosimbisa muviri, uye vanhu vari kutsvaga kusimudzira chitarisiko chavo kana toni-kuvimba. Inobatsirawo kune vanhu vane ruvara rwakanaka kana kuti vanopisa nezuva, sezvo ichideredza dambudziko rekuita gomarara reganda.

Icho chigadzirwa chemhando yepamusoro chakagadzirwa kune yakakwira tsika dzekuchengetedza uye kuchena. Yakagadzirwa kubva kumhando yepamusoro-soro, icing kuti yakachengeteka kushandiswa uye haina kubereka chero zvinhu zvakashata.

Mukupedzisa, Melanotan II ishasha yekupisa inogona kukubatsira iwe kuwana iyo yeganda toni yaunobvunza. Yakachengeteka, inoshanda, uye iri nyore kushandisa.Zvisinei, Ndiwo mubairo wakakunakira iwe, Kana iwe uchida kuwana tani pasina kuburitsa ganda rako kune njodzi UV shafts.

 

Basic Information

Product Name: Melanotan II; MTIl; Melanotan 2

Zvinoteverana : chigadzirwa-363-58

CAS: 121062-08-6

MF:C50H69N15O9

MW:1024.18

EINECS: 1308068-626-2

MDL Nhamba:MFCD01318793

Structural fomula:

chigadzirwa-1-1

Origin: China

Kushandisa: Peptide

Nguva Yekutumira: mune stock

 

Technical Specification

Product Name

Melanotan II

CAS Nha.

121062-08-6

Molecular Formula

C50H69N15O9

Molecular Weight

1024.178

KUYARA

Specification

RESULT

Kuonekwa

Muchena kana hupfu hwakachena

Shanduko

Solubility

Kusunungura mumvura

Shanduko

Zvemumvura (Karl Fischer)

≤ 8.0%

4.9%

Acetic Acid (NeHPLC)

≤ 15.0%

9.9%

Peptide Purity (NeHPLC)

≥ 98.0%

99.86%

 

Related Substance

(NeHPLC)

Zvose Zvisina Kuchena(%) ≤ 2.0%

0%

Kusachena kwakakura kumwechete(%) ≤ 1.0%

0.05%

Assay

95.0 ~105.0%

101.15%

mhedziso

Iyi batch yechigadzirwa inoenderana neyakajairwa bhizinesi uye inokwanisa.

Package: 1g; 100g; 1000g kana zvinoenderana nezvaunoda

Kuchengeta: Mumudziyo usina mhepo, wakadzivirirwa kubva kuchiedza, patembiricha ye2 ℃ kusvika 8 ℃

Sherufu Hupenyu 24 mwedzi

chigadzirwa-731-501

chinangwa

Melanotan-II powder irabhoritari inogadzirwa kemikari inofanana nemahomoni ari mumuviri unofa. Melanotan II yakaratidza kuve ine melanogenesis (tanning) uye aphrodisiac zvinhu pavanhu.

 

Biological Activity

Melanotan II (MTII) inogadzirwa melanocortin receptor agonist. Injectable peptide hormone inogona kukurudzira kupiswa.

 

In vitro kuongorora

In vitro yekuongorora inosanganisira Melanotan 2 inowanzotarisa pakunzwisisa kwayo svikiro rechiito, receptor runyorwa hukama, uye cellular mhinduro. Dzimwe nzvimbo dzekufunda dzinosanganisira

Receptor Rondedzero Zvidzidzo Vaongorori vanoongorora kuti MTII inodyidzana sei nemelanocortin receptors (MC1R, MC3R, MC4R, MC5R) uye mamwe ma receptors kuti atore zvinhu zvayo.

Cellular Signaling Pathways Zvidzidzo zvinoongorora nzira dzemukati dzemasaini dzinoitwa neMTII, dzakafanana necAMP chigadzirwa, MAPK/ERK kusaina, uye kusaina calcium.

Melanogenesis MTII's kugona kumutsa melanin chigadzirwa mumamelanocytes inonyanya kufarira mu vitro. Vaongorori vanoongorora zvinhu zvaro pa melanin conflation enzymes yakafanana netyrosinase, tyrosinase-inoenderana protein 1 (TRP-1), uye tyrosinase-inoenderana protein 2 (TRP-2).

Cytotoxicity uye Cell Viability kuongorora kuchengetedzwa kweMTII kunosanganisira kuongorora zvinhu zvayo zve cytotoxic pamhando dzakasiyana dzemasero uye kukanganisa kwayo pakushanda kwesero.

Anti-kuzvimba mapasuru Kumwe kuongorora kunoratidza kuti inogona kuchengetedza anti-kuzvimba mapasuru, ayo anogona kuongororwa zvakanyanya in vitro.

Kuita Zvepabonde In vitro zvidzidzo zvinogona kuferefeta zvinhu zveMTII pane neuronal maseketi uye neurotransmitter kuburitswa kunobatanidzwa mukunakidzwa kwepabonde.

Appetite Regulation exploration inogona kuongorora yakanangana nekugadzirisa neuropeptides inobatanidzwa mukutonga kwechido, yakafanana nealpha-MSH, neuropeptide Y (NPY), uye agouti-inoenderana protein (AgRP).

In vitro zvidzidzo zvinopa kukosha kwekunzwisisa mumamorekuru echiito cheMTII uye inogona kutungamira kuongorora nekusimudzira, kusanganisira mashandiro ekugadzirisa. zvakadaro, zvakakosha kududzira zvakawanikwa izvi munharaunda yein vivo zvidzidzo uye miedzo yekiriniki kuti unzwisise kambasi yakazara yezvinhu zvayo uye nhoroondo yekuchengetedza.

 

In vivo kuongorora

In vivo exploration inosanganisira Melanotan II(MT- II) ine chinangwa chekunzwisisa zvinhu zvayo uye nekuita mashandiro ekugadzirisa mune zvipenyu. Dzimwe nzvimbo dzekufunda muMTII mu vivo kuongorora dzinosanganisira

Skin Saturation Chimwe chezvinhu zvekutanga zveMelanotan II ndechekukurudzira kuzara kweganda. In vivo zvidzidzo zvinoongorora nguva, kusimba, uye melanocyte activation maitiro anotevera Melanotan II kutonga.

Kuita Zvepabonde peptide melanotan yakadzidzwa nekuda kwekuita kwayo kuti iwedzere kuita zvepabonde uye kunakidzwa. Mhando dzemhuka dzinoshandiswa kuongorora zvinhu zveMT-II pane zvepabonde geste, libido, uye erectile basa.

Appetite Regulation uye Weight Loss MT II inogona kunge iine appetite- inodzvinyirira mapasuru. Zvidzidzo zvemu vivo zvinoongorora zvinhu zvaro pane zvekuisa chikafu, kushaya chikafu, kuonda, uye metabolic paramita.

Inflammation uye Immune Response zvinhu zvaro zvisingabvumirwe-kuzvimba zvinotariswa mumhando dzemhuka dzemamiriro ekumukira. Vaedze vanoongorora maitiro ayo pane cytokine chigadzirwa, panjodzi cell activation, uye kuzvimba tauro.

Cardiovascular Health Studies inoongorora zvinhu zvemoyo zveMT II, ​​zvinosanganisira kudzora kweBP, vascular function, uye cardiac redoing.

Dziviriro kubva kuUV-Induced Damage MT II yakaongororwa kuitira kuti ivhare kukuvara kweganda kweUV, kusanganisira kupisa kwezuva, kukuvara kweDNA, uye kukura kwegomarara reganda. Mhando dzemhuka dzinoshandiswa kufungidzira mapasuru ayo emifananidzo.

Neuroprotection uye Neurological hosha maitiro ayo pane yepakati tsinga sisitimu inodzidzwa, kusanganisira yayo isina kujeka neuroprotective zvinhu uye chikamu chayo muzvirwere zvetsinga zvakafanana nekunyunyuta kwaParkinson uye multiple sclerosis.

Chengetedzo uye Zveparutivi zvinhu In vivo exploration inoongorora chengetedzo chimiro cheMT II, ​​ichiongorora zvinhu zveparutivi, chepfu, uye zvinhu zvenguva refu panhengo dzine mavara uye masisitimu.

Zvidzidzo zvemu vivo zvinopa ruzivo rwakakosha pazvinhu zvemuviri, lozenge optimization, uye mashandiro akajeka ekugadzirisa kweMT II. Zvakakosha kuziva kuti kunyange zvazvo zvidzidzo zvemhuka zvichigona kupa ruzivo rwakakosha, mimwe miedzo yekiriniki inodiwa kusimbisa zvakawanikwa izvi uye kufungidzira kushanda nekuchengetedzwa kweMelanotan II muvanhu.

 

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